Testing behaviour may bias observational studies of vaccine effectiveness
Field | Value | Language |
dc.contributor.author | Glasziou, Paul | en_AU |
dc.contributor.author | McCaffery, Kirsten | en_AU |
dc.contributor.author | Cvejic, Erin | en_AU |
dc.contributor.author | Batcup, Carys | en_AU |
dc.contributor.author | Ayre, Julie | en_AU |
dc.contributor.author | Pickles, Kristen | en_AU |
dc.contributor.author | Bonner, Carissa | en_AU |
dc.date.accessioned | 2022-04-28T02:45:24Z | |
dc.date.available | 2022-04-28T02:45:24Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/2123/28412 | |
dc.description.abstract | Backgroun Recent observational studies have suggested that vaccines for the omicron variant of SARS-Cov2 may have little or no effect in preventing infection. However, the observed effects may be confounded by patient factors and preventive behaviours or vaccine-related differences in testing behaviour. To assess the potential degree of confounding, we aimed to estimate differences in testing behaviour between unvaccinated and vaccinated populations. Methods We recruited 1,526 Australian adults for an online randomised study about COVID testing between October and November 2021, and collected self-reported vaccination status and three measures of COVID-19 testing behaviour. We examined the association between testing intentions and vaccination status in the cross-sectional baseline data of this trial. Results Of the 1,526 participants (mean age 31 years): 22% had a COVID-19 test in the past month and 61% ever; 17% were unvaccinated, 11% were partially vaccinated (1 dose), 71% were fully vaccinated (2+ doses). Fully vaccinated participants were twice as likely (RR 2.2; 95% CI 1.8 to 2.8) to report positive COVID testing intentions than those who were unvaccinated (p | en_AU |
dc.language.iso | en | en_AU |
dc.subject | COVID-19 | en_AUI |
dc.subject | Coronavirus | en_AUI |
dc.title | Testing behaviour may bias observational studies of vaccine effectiveness | en_AU |
dc.type | Preprint | en_AU |
dc.identifier.doi | 10.1101/2022.01.17.22269450 | |
dc.relation.other | National Heart Foundation of Australia | en_AU |
dc.relation.other | National Health and Medical Research Council | en_AU |
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