Studying the post-COVID-19 condition: research challenges, strategies, and importance of Core Outcome Set development
Type
ArticleAuthor/s
Munblit, DanielNicholson, Timothy R.
Needham, Dale M.
Seylanova, Nina
Parr, Callum
Chen, Jessica
Kokorina, Alisa
Sigfrid, Louise
Buonsenso, Danilo
Bhatnagar, Shinjini
Thiruvengadam, Ramachandran
Parker, Ann M.
Preller, Jacobus
Avdeev, Sergey
Klok, Frederikus A.
Tong, Allison
Diaz, Janet V.
Groote, Wouter De
Schiess, Nicoline
Akrami, Athena
Simpson, Frances
Olliaro, Piero
Apfelbacher, Christian
Rosa, Regis Goulart
Chevinsky, Jennifer R.
Saydah, Sharon
Schmitt, Jochen
Guekht, Alla
Gorst, Sarah L.
Genuneit, Jon
Reyes, Luis Felipe
Asmanov, Alan
O'Hara, Margaret E.
Scott, Janet T.
Michelen, Melina
Stavropoulou, Charitini
Warner, John O.
Herridge, Margaret
Williamson, Paula R.
Abstract
BackgroundA substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, ...
See moreBackgroundA substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to as long COVID but also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-COVID-19 condition, could become a significant global health burden.Main textWhile the number of studies investigating the post-COVID-19 condition is increasing, there is no agreement on how this new disease should be defined and diagnosed in clinical practice and what relevant outcomes to measure. There is an urgent need to optimise and standardise outcome measures for this important patient group both for clinical services and for research and to allow comparing and pooling of data.ConclusionsA Core Outcome Set for post-COVID-19 condition should be developed in the shortest time frame possible, for improvement in data quality, harmonisation, and comparability between different geographical locations. We call for a global initiative, involving all relevant partners, including, but not limited to, healthcare professionals, researchers, methodologists, patients, and caregivers. We urge coordinated actions aiming to develop a Core Outcome Set (COS) for post-COVID-19 condition in both the adult and paediatric populations.
See less
See moreBackgroundA substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to as long COVID but also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-COVID-19 condition, could become a significant global health burden.Main textWhile the number of studies investigating the post-COVID-19 condition is increasing, there is no agreement on how this new disease should be defined and diagnosed in clinical practice and what relevant outcomes to measure. There is an urgent need to optimise and standardise outcome measures for this important patient group both for clinical services and for research and to allow comparing and pooling of data.ConclusionsA Core Outcome Set for post-COVID-19 condition should be developed in the shortest time frame possible, for improvement in data quality, harmonisation, and comparability between different geographical locations. We call for a global initiative, involving all relevant partners, including, but not limited to, healthcare professionals, researchers, methodologists, patients, and caregivers. We urge coordinated actions aiming to develop a Core Outcome Set (COS) for post-COVID-19 condition in both the adult and paediatric populations.
See less
Date
2022Funding information
Medical Research Council
World Health Organization
Share