Experiences in improving membership engagement and grant success for clinical research networks in particular for the Australian melanoma and skin cancer community

Abstract

Introduction The purpose of the thesis is to investigate the important role of clinical trial networks (CTNs), specifically the national cancer cooperative trial groups (CCTGs), have in growing high-quality memberships and optimising grant success to support the undertaking of a greater number of investigator-initiated, high-quality, Australian-led, skin cancer clinical trials. This is critically important in Australia which has the highest skin cancer burden globally.

Methodology Experiences from CTNs with a particular focus on the skin CCTG have been evaluated. Two studies have been undertaken.

Results The essay comprises four chapters that deals with CTN function including membership optimisation and grant application success. Significant underlying themes were found. CTNs need: • to have strong leadership, clear vision and robust governance; • to be supported as they mature and reorganise; • to build a strong culture which can enhance members’ commitment to the cause; • to use resources wisely; • to facilitate appropriate communications with and across all stakeholders when conducting RCTs; • to encourage membership diversity and research participation; and • to encourage their members to have a flexible mindset to optimise research success.

Conclusions The thesis provides a significant resource for the CTN and CCTG community. The studies led to significant advances in the national capacity to support an international membership which is capable of securing funding to complete high-quality, Australian-led, investigator-initiated skin cancer research. The thesis demonstrates that a dedicated skin CCTG has a real place globally. The thesis provides a platform for further research in improving CTN function, reducing trial failure and improvements translating results to impact on community practice.