The Association of Surgical Margins and Local Recurrence in Women with Ductal Carcinoma In Situ Treated with Breast-Conserving Therapy: A Meta-Analysis.
Type
ArticleAuthor/s
Marinovich, Michael LukeAzizi, Lamiae
Macaskill, Petra
Irwig, Les
Morrow, Monica
Solin, Lawrence J.
Houssami, Nehmat
Abstract
Purpose: There is no consensus on adequate negative margins in breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). We systematically reviewed the evidence on margins in BCS for DCIS.
Methods: A study-level meta-analysis of local recurrence (LR), microscopic margin status and threshold distance for negative margins. LR proportion was modeled using random-effects logistic meta-regression (frequentist) and network meta-analysis (Bayesian) that allows for multiple margin distances per study, adjusting for follow-up time.Purpose: There is no consensus on adequate negative margins in breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). We systematically reviewed the evidence on margins in BCS for DCIS.
Methods: A study-level meta-analysis of local recurrence (LR), microscopic margin status and threshold distance for negative margins. LR proportion was modeled using random-effects logistic meta-regression (frequentist) and network meta-analysis (Bayesian) that allows for multiple margin distances per study, adjusting for follow-up time.
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Date
2016Source title
Annals of Surgical OncologyVolume
23Publisher
Springer LinkLicence
Copyright All Rights ReservedFaculty/School
Faculty of Medicine and Health, Sydney School of Public HealthShare