Agreement between digital breast tomosynthesis and pathologic tumour size for staging breast cancer, and comparison with standard mammography.
Field | Value | Language |
dc.contributor.author | Marinovich, Luke | |
dc.contributor.author | Bernardi, Daniela | |
dc.contributor.author | Macaskill, Petra | |
dc.contributor.author | Ventriglia, Anna | |
dc.contributor.author | Sabatino, Vincenzo | |
dc.contributor.author | Houssami, Nehmat | |
dc.date.accessioned | 2021-08-19T05:45:59Z | |
dc.date.available | 2021-08-19T05:45:59Z | |
dc.date.issued | 2019 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/25879 | |
dc.description.abstract | Purpose: Tomosynthesis is proposed to improve breast cancer assessment and staging. We compared tomosynthesis and mammography in estimating the size of newly-diagnosed breast cancers. Methods: All pathologically-confirmed cancers detected in the STORM-2 trial (90 cancers, 85 women) were retrospectively measured on tomosynthesis by two independent readers. One reader also measured cancers on mammography. Relative mean differences (MDs) and 95% limits of agreement (LOA) with pathology were estimated for tomosynthesis and mammography within a single reader (Analysis 1) and between two readers (Analysis 2). Results: Where cancers were detected and hence measured by both tests, tomosynthesis overestimated pathologic size relative to mammography (Analysis 1: MD 5% versus 1%, Analysis 2: 7% versus 3%; P = 0.10 both analyses). There was similar, large measurement variability for both tests (LOA range: −60% to +166%). Overestimation by tomosynthesis was attributable to the subgroup with dense breasts (MDs = 12–13% versus 4% for mammography). There was low average bias for both tests in the low-density subgroup (MDs = 0–4%). LOA were larger in dense breasts for both tomosynthesis and mammography (P ≤ 0.02 all comparisons). Cancers detected only by tomosynthesis were more frequently in dense breasts (60–68%): for those tumours size was estimated with increased measurement variability (LOA ranging from −75% to +293%). | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | Elsevier | en_AU |
dc.relation.ispartof | The Breast | en_AU |
dc.rights | Copyright All Rights Reserved | en_AU |
dc.subject | Tomosynthesis | en_AU |
dc.subject | Mammography | en_AU |
dc.subject | Breast cancer | en_AU |
dc.subject | Staging | en_AU |
dc.subject | Tumour size | en_AU |
dc.subject | Accuracy | en_AU |
dc.title | Agreement between digital breast tomosynthesis and pathologic tumour size for staging breast cancer, and comparison with standard mammography. | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 1112 Oncology and Carcinogenesis | en_AU |
dc.subject.asrc | 1117 Public Health and Health Services | en_AU |
dc.identifier.doi | 10.1016/j.breast.2018.11.001 | |
usyd.faculty | SeS faculties schools::Faculty of Medicine and Health::Sydney School of Public Health | en_AU |
workflow.metadata.only | Yes | en_AU |
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