Effectiveness of digital breast tomosynthesis (3D-mammography) in population breast cancer screening: a protocol for a collaborative individual participant data (IPD) meta-analysis
Field | Value | Language |
dc.contributor.author | Houssami, Nehmat | |
dc.contributor.author | Lang, Kristina | |
dc.contributor.author | Hofvind, Solveig | |
dc.contributor.author | Zackrisson, Sophia | |
dc.contributor.author | Bernardi, Daniela | |
dc.contributor.author | Hunter, Kylie | |
dc.contributor.author | Askie, Lisa | |
dc.contributor.author | Skaane, Per | |
dc.date.accessioned | 2021-07-19T02:40:44Z | |
dc.date.available | 2021-07-19T02:40:44Z | |
dc.date.issued | 2017 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/25717 | |
dc.description.abstract | Background: There is accumulating evidence that digital breast tomosynthesis, referred to as 3D-mammography in this protocol, improves screen-detection measures compared to standard 2D-mammography in the context of population screening for breast cancer. However, the effect of 3D-mammography at follow-up of screened women is not yet known: it is unknown whether additional cancer detection from 3D-mammography leads to incremental screening benefit through a reduction of interval cancers, or whether it is mostly over-detecting indolent cancers. Methods: The aim of this study is to examine whether 3D-mammography population screening improves breast cancer screening effectiveness by reducing interval cancer rates compared to standard digital (2D) mammography screening, using individual participant data (IPD) meta-analysis. In this protocol, we outline the research plan which includes systematic identification of studies eligible to contribute data into the IPD meta-analysis, and sourcing and assembling IPD for participants screened with 3D-mammography (3D alone or integrated 2D/3D or integrated 2Dsynthetic/3D) and comparison participants screened with 2D-mammography (standard of care in breast screening). The primary end-point of this work is the interval breast cancer rate per 10,000 screens for 3D-mammography versus 2D-mammography screening. The IPD meta-analysis will also assess secondary outcomes including: screening sensitivity, cancer detection rates, cancer (prognostic) characteristics, and recall rates, for 3D-mammography versus 2D-mammography screening. The use of IPD meta-analysis will allow stratification of results by age and breast density, and will also facilitate analysis of cancer histological (prognostic) characteristics. Discussion: Finalization of data collection procedures and analysis plans will be complete by the end of 2017. Data collection will occur from late 2017 to late 2018 (screen-detection measures: cancer detection and recall data) and from mid-2018 to mid-2019 (interval cancer data). Results of detection measures should be available by 2019, and interval cancer results in 2020. By addressing the critical evidence gap on whether 3D-mammography screening reduces interval cancer rates (compared to 2D-mammography), we expect that our findings will inform timely translation of 3D-mammography technology into breast screening practice in population-based health programs. | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | AME Publ Co | en_AU |
dc.relation.ispartof | Translational Cancer Research | en_AU |
dc.rights | Creative Commons Attribution-NoDerivatives 4.0 | en_AU |
dc.subject | breast neoplasms | en_AU |
dc.subject | mammography | en_AU |
dc.subject | mass screening | en_AU |
dc.title | Effectiveness of digital breast tomosynthesis (3D-mammography) in population breast cancer screening: a protocol for a collaborative individual participant data (IPD) meta-analysis | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 1112 Oncology and Carcinogenesis | en_AU |
dc.identifier.doi | 10.21037/tcr.2017.06.39 | |
dc.relation.other | National Breast Cancer Foundation LF-16-001 | |
usyd.faculty | SeS faculties schools::Faculty of Medicine and Health::Sydney School of Public Health | en_AU |
usyd.citation.volume | 6 | en_AU |
usyd.citation.issue | 4 | en_AU |
usyd.citation.spage | 869 | en_AU |
usyd.citation.epage | 877 | en_AU |
workflow.metadata.only | No | en_AU |
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