Real-Time Image Guided Ablative Prostate Cancer Radiation Therapy: Results From the TROG 15.01 SPARK Trial
Field | Value | Language |
dc.contributor.author | Keall, Paul | |
dc.contributor.author | Nguyen, Doan Trang | |
dc.contributor.author | O'Brien, Ricky | |
dc.contributor.author | Hewson, Emily | |
dc.contributor.author | Ball, Helen | |
dc.contributor.author | Poulsen, Per | |
dc.contributor.author | Booth, Jeremy | |
dc.contributor.author | Greer, Peter | |
dc.contributor.author | Hunter, Perry | |
dc.contributor.author | Wilton, Lee | |
dc.contributor.author | Bromley, Regina | |
dc.contributor.author | Kipritidis, John | |
dc.contributor.author | Eade, Thomas | |
dc.contributor.author | Kneebone, Andrew | |
dc.contributor.author | Hruby, George | |
dc.contributor.author | Moodie, Trevor | |
dc.contributor.author | Hayden, Amy | |
dc.contributor.author | Turner, Sandra | |
dc.contributor.author | Arumugam, Sankar | |
dc.contributor.author | Sidhom, Mark | |
dc.contributor.author | Harcastle, Nick | |
dc.contributor.author | Siva, Shankar | |
dc.contributor.author | Tai, Keen-Hun | |
dc.contributor.author | Gebski, Val | |
dc.contributor.author | Martin, Jarad | |
dc.date.accessioned | 2021-01-13T05:45:46Z | |
dc.date.available | 2021-01-13T05:45:46Z | |
dc.date.issued | 2020 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/24298 | |
dc.description.abstract | Purpose: Kilovoltage intrafraction monitoring (KIM) is a novel software platform implemented on standard radiation therapy systems and enabling real-time image guided radiation therapy (IGRT). In a multi-institutional prospective trial, we investigated whether real-time IGRT improved the accuracy of the dose patients with prostate cancer received during radiation therapy. Methods and materials: Forty-eight patients with prostate cancer were treated with KIM-guided SABR with 36.25 Gy in 5 fractions. During KIM-guided treatment, the prostate motion was corrected for by either beam gating with couch shifts or multileaf collimator tracking. A dose reconstruction method was used to evaluate the dose delivered to the target and organs at risk with and without real-time IGRT. Primary outcome was the effect of real-time IGRT on dose distributions. Secondary outcomes included patient-reported outcomes and toxicity. Results: Motion correction occurred in ≥1 treatment for 88% of patients (42 of 48) and 51% of treatments (121 of 235). With real-time IGRT, no treatments had prostate clinical target volume (CTV) D98% dose 5% less than planned. Without real-time IGRT, 13 treatments (5.5%) had prostate CTV D98% doses 5% less than planned. The prostate CTV D98% dose with real-time IGRT was closer to the plan by an average of 1.0% (range, -2.8% to 20.3%). Patient outcomes showed no change in the 12-month patient-reported outcomes compared with baseline and no grade ≥3 genitourinary or gastrointestinal toxicities. Conclusions: Real-time IGRT is clinically effective for prostate cancer SABR. | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | Elsevier | en_AU |
dc.relation.ispartof | International Jounral of Radiation Oncology, Bioogy, Physics | en_AU |
dc.rights | Copyright All Rights Reserved | en_AU |
dc.subject | image-guided radiation therapy | en_AU |
dc.title | Real-Time Image Guided Ablative Prostate Cancer Radiation Therapy: Results From the TROG 15.01 SPARK Trial | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 0299 Other Physical Sciences | en_AU |
dc.identifier.doi | 10.1016/j.ijrobp.2020.03.014 | |
dc.relation.nhmrc | 1112096 | |
dc.relation.other | 1081534 | |
usyd.faculty | SeS faculties schools::Faculty of Medicine and Health | en_AU |
usyd.department | Central Clinical School | en_AU |
usyd.citation.volume | 107 | en_AU |
usyd.citation.issue | 3 | en_AU |
usyd.citation.spage | 530 | en_AU |
usyd.citation.epage | 538 | en_AU |
workflow.metadata.only | No | en_AU |
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