Faculty of Medicine and Health: Recent submissions
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Therapeutic misunderstandings in modern research
Published 2023Clinical trials play a crucial role in generating evidence about healthcare interventions and improving outcomes for current and future patients. For individual trial participants, however, there are inevitably trade-offs ...Open AccessArticle -
Networking One Health laboratories in ASEAN to tackle Antimicrobial Resistance
Published 2023-12-21This report provides an overview of the key findings and recommendations derived from a series of meetings exploring the One Health research and networking capacity in Cambodia, Laos PDR, and Vietnam in the context of ...Open AccessReport, Technical -
Fluorinated Analogues of Desferrioxamine B from Precursor-Directed Biosynthesis Provide New Insight into the Capacity of DesBCD
Published 2018The siderophore desferrioxamine B (DFOB, 1) native to Streptomyces pilosus is biosynthesized by the DesABCD enzyme cluster. DesA-mediated decarboxylation of l-lysine gives 1,5-diaminopentane (DP) for processing by DesBCD. ...Open AccessArticle -
Engineering a cleavable disulfide bond into a natural product siderophore using precursor-directed biosynthesis
Published 2018An analogue of the bacterial siderophore desferrioxamine B (DFOB) containing a disulfide motif in the backbone was produced from Streptomyces pilosus cultures supplemented with cystamine. Cystamine competed against native ...Open AccessPreprint -
Siderophores and iron transport
Published 2023Siderophores are low-molecular-weight organic compounds produced by bacteria and fungi for Fe(III) supply. Bacteria and fungi biosynthesize siderophores in response to low iron, which are released into the local environment ...Book chapter