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Browsing Faculty of Medicine and Health by subject "02 Physical Sciences"

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    • Adapting to the motion of multiple independent targets using multileaf collimator tracking for locally advanced prostate cancer: Proof of principle simulation study. 

      Hewson, E; Ge, Y; O'Brien, R; Roderick, S; Bell, L; Poulsen, P; Eade, T; Booth, J; Keall, P; Nguyen, DT
      Published 2021
      Purpose: For patients with locally advanced cancer, multiple targets are treated simultaneously with radiotherapy. Differential motion between targets can compromise the treatment accuracy, yet there are currently no methods ...
      Open Access
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    • Dose-based optimisation for multi-leaf collimator tracking during radiation therapy. 

      Mejnertsen, L; Hewson, E; Nguyen, DT; Booth, J; Keall, P
      Published 2021
      Motion in the patient anatomy causes a reduction in dose delivered to the target, while increasing dose to healthy tissue. Multi-leaf collimator (MLC) tracking has been clinically implemented to adapt dose delivery to ...
      Open Access
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    • The first prospective implementation of markerless lung target tracking in an experimental quality assurance procedure on a standard linear accelerator. 

      Mueller, M; Zolfaghari, R; Briggs, A; Furtado, H; Booth, J; Keall, P; Nguyen, D; O'Brien, R; Shieh, CC
      Published 2020-01-01
      The ability to track tumour motion without implanted markers on a standard linear accelerator (linac) could enable wide access to real-time adaptive radiotherapy for cancer patients. We previously have retrospectively ...
      Open Access
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    • Pelvic organ motion and dosimetric implications during horizontal patient rotation for prostate radiation therapy. 

      Buckley, J; Dowling, J; Sidhom, M; Liney, G; Rai, R; Metcalfe, p; Holloway, L; Keall, P
      Published 2021
      Purpose: Gantry-free radiation therapy systems utilizing patient rotation would be simpler and more cost effective than the conventional gantry-based systems. Such a system could enable the expansion of radiation therapy ...
      Open Access
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    • Quantification of the geometric uncertainty when using implanted markers as a surrogate for lung tumor motion. 

      Hardcastle, N; Briggs, A; Caillet, V; Angelis, G; Chrystall, D; Jayamanne, D; Shepherd, M; Harris, B; Haddad, C; Eade, T; Keall, P; Booth, J
      Published 2021
      Background: Fiducial markers are used as surrogates for tumor location during radiation therapy treatment. Developments in lung fiducial marker and implantation technology have provided a means to insert markers endobronchially ...
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