The University of Sydney: Recent submissions
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The proteomic, immune, and antigenic profiling of colorectal cancer for the design of CAR-T cell therapies
Published 2025Colorectal cancer (CRC) is forecast to become the leading cause of cancer and cancer-related deaths by 2040. Although it predominates in older patients, there has been a rise in young onset disease. Efforts have been made ...USyd AccessThesis -
Determinants of alloreactive T cell fate and function
Published 2024Expression of donor MHC class I in recipient hepatocytes using adeno-associated viral (AAV) vectors induces tolerance to subsequent skin grafts bearing the same mismatched MHC, even in the presence of pre-existing immune ...USyd AccessThesis -
Genetic profiling of phaeochromocytoma and paraganglioma: towards precision medicine
Published 2024Phaeochromoctyoma and paraganglioma (PC/PGL) are rare neuroendocrine tumours of neural crest origin, arising within the adrenal medulla and sympathetic/parasympathetic chain. High heritability is a unique feature of PC/PGL ...Open AccessThesis -
Instrument Assignment Based on LATE Results with Defiers
Published 2025-08-08While most previous studies have focused on treatment assignment, this thesis emphasises instrument assignment to estimate Local Average Treatment Effects (LATE). We introduce a refined methodology to address limitations ...Open AccessThesis -
Formulation of probiotics and bacteriophages for respiratory delivery
Published 2025This thesis explores biological agents that confers benefits in maintaining lung health and investigates the feasibility of localised delivery to the lungs to maximise efficacy and minimise systemic adverse events. Probiotics ...USyd AccessThesis