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dc.contributor.authorHsu, B
dc.contributor.authorHirani, V
dc.contributor.authorCumming, R
dc.contributor.authorNaganathan, V
dc.contributor.authorBlyth, F
dc.contributor.authorWright, F
dc.contributor.authorWaite, L
dc.contributor.authorSeibel, M
dc.contributor.authorHandelsman, D
dc.contributor.authorLe Couteur, D
dc.date.accessioned2019-08-26T06:18:59Z
dc.date.available2019-08-26T06:18:59Z
dc.date.issued2017-07-28
dc.identifier.citationBenjumin Hsu, Vasant Hirani, Robert G Cumming, Vasi Naganathan, Fiona M Blyth, Fredrick C Wright, Louise M Waite, Markus J Seibel, David J Handelsman, David G Le Couteur, Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project, The Journals of Gerontology: Series A, Volume 74, Issue 6, June 2019, Pages 835–841, https://doi.org/10.1093/gerona/glx142en_AU
dc.identifier.urihttp://hdl.handle.net/2123/20967
dc.description.abstractBackground Previous studies demonstrated associations between IL-6 and frailty, but associations between a wide range of cytokines, chemokines, and growth factors with prevalent and incident frailty has not been studied. Methods Community-dwelling men aged more than 75 enrolled in the 5-year and 8-year follow-up of the CHAMP study were assessed. Twenty-seven inflammatory biomarkers were measured using the Bio-Plex Pro Human Cytokine 27-plex Assay kit at 5-year follow-up. Frailty was determined using the Fried frailty phenotype (FP) and Rockwood frailty index (FI) at both time-points. Age, body mass index, smoking, alcohol, and comorbidity were also assessed. Results In cross-sectional analysis of the 5-year follow-up, the unadjusted odds ratio (OR) for frail versus robust evaluated by the FP showed significant associations for IL-6 (OR: 1.56, 95% confidence interval [CI]: 1.23–1.98) and IL-8 (OR: 1.28, 95% CI: 1.00–1.63). IL-6 remained significantly associated in the age-adjusted (OR: 1.58, 95% CI: 1.21–2.05) and multivariable-adjusted model (OR: 1.54, 95% CI: 1.16–2.05). No associations were observed between pre-frail versus robust. In longitudinal unadjusted analysis, IL-8 (OR: 1.32, 95% CI: 1.03–1.70) and IP-10 (OR: 1.32, 95% CI: 1.03–1.70) at 5-year predicted incident frailty at 8-year follow-up. IL-8 remained longitudinally associated with incident frailty after age (OR: 1.34, 95% CI: 1.03–1.75) but not multivariable (OR: 1.20, 95% CI: 0.98–1.70) adjustment. Similar results were seen using the FI. None of the other biomarkers had significant associations with incident frailty. Conclusions Our findings suggest that IL-6 and IL-8 may be cross-sectionally associated with frailty and that all measured inflammatory biomarkers were not causally related to frailty. Together with previous studies, the results suggest that frailty is specifically linked to IL-6 and IL-8 rather than simply representing a nonspecific pan-inflammatory condition.en_AU
dc.description.sponsorshipNHMRC, Sydney Medical School Foundation, Ageing and Alzheimer’s Institute, Centre for Oral Health Strategy, NSW Health.en_AU
dc.language.isoen_AUen_AU
dc.publisherOxford University Pressen_AU
dc.relationNHMRC 301916en_AU
dc.rightsThis is a pre-copyedited, author-produced version of an article accepted for publication in The Journals of Gerontology: Series A following peer review. The version of record Benjumin Hsu, Vasant Hirani, Robert G Cumming, Vasi Naganathan, Fiona M Blyth, Fredrick C Wright, Louise M Waite, Markus J Seibel, David J Handelsman, David G Le Couteur, Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project, The Journals of Gerontology: Series A, Volume 74, Issue 6, June 2019, Pages 835–841 is available online at: https://doi.org/10.1093/gerona/glx142en_AU
dc.titleCross-sectional and longitudinal relationships between inflammatory biomarkers and frailty in community-dwelling older men: the Concord Health and Ageing in Men Projecten_AU
dc.typeArticleen_AU
dc.subject.asrcFoR::111799 - Public Health and Health Services not elsewhere classifieden_AU
dc.identifier.doi10.1093/gerona/glx142
dc.type.pubtypePost-printen_AU


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