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dc.contributor.authorAl Mazari, Ali
dc.date.accessioned2007-08-21
dc.date.available2007-08-21
dc.date.issued2007-03-01
dc.identifier.urihttp://hdl.handle.net/2123/1907
dc.description.abstractABSTRACT Despite the extensive quantitative and qualitative knowledge about therapeutic regimens and the molecular biology of HIV/AIDS, the eradication of HIV infection cannot be achieved with available antiretroviral regimens. HIV drug resistance remains the most challenging factor in the application of approved antiretroviral agents. Previous investigations and existing HIV/AIDS models and algorithms have not enabled the development of long-lasting and preventive drug agents. Therefore, the analysis of the dynamics of drug resistance and the development of sophisticated HIV/AIDS analytical algorithms and models are critical for the development of new, potent antiviral agents, and for the greater understanding of the evolutionary behaviours of HIV. This study presents novel computational methods for the analysis of drug-resistance dynamics, including: viral sequences, phenotypic resistance, immunological and virological responses and key clinical data, from HIV-infected patients at Royal Prince Alfred Hospital in Sydney. The lability of immunological and virological responses is analysed in the context of the evolution of antiretroviral drug-resistance mutations. A novel Bayesian algorithm is developed for the detection and classification of neutral and adaptive mutational patterns associated with HIV drug resistance. To simplify and provide insights into the multifactorial interactions between viral populations, immune-system cells, drug resistance and treatment parameters, a Bayesian graphical model of drug-resistance dynamics is developed; the model supports the exploration of the interdependent associations among these dynamics.en
dc.rightsThe author retains copyright of this thesis.
dc.rights.urihttp://www.library.usyd.edu.au/copyright.html
dc.subjectComputational Methods, Bioinformatics, Biomedical Informatics, Algorithms, HIV Models, HIV Drug Resistance, Immunoloigcal and Virological Dynamicsen
dc.titleComputational methods for the analysis of HIV drug resistance dynamicsen
dc.typeThesisen_AU
dc.date.valid2007-01-01en
dc.type.thesisDoctor of Philosophyen_AU
usyd.facultyFaculty of Engineering and Information Technologies, School of Information Technologiesen_AU
usyd.degreeDoctor of Philosophy Ph.D.en_AU
usyd.awardinginstThe University of Sydneyen_AU


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