Elevated Liver Enzymes and Mortality in Older Individuals: A Prospective Cohort Study
Field | Value | Language |
dc.contributor.author | Mahady, Suzanne E | |
dc.contributor.author | Wong, G | |
dc.contributor.author | Turner, RM | |
dc.contributor.author | Mitchell, P | |
dc.contributor.author | Macaskill, P | |
dc.contributor.author | Craig, JC | |
dc.contributor.author | George, Jacob | |
dc.date.accessioned | 2017-02-20 | |
dc.date.available | 2017-06-26 | |
dc.date.issued | 2016-01-01 | |
dc.identifier.citation | Mahady SE, Wong G, Turner R, Mitchell P, Macaskill P, Craig JC, George J. Elevated liver enzymes and mortality in older individuals: a prospective cohort study. Journal of Clinical Gastroenterology, 2016. doi: 10.1097/MCG.0000000000000622. | en_AU |
dc.identifier.uri | http://hdl.handle.net/2123/16385 | |
dc.description.abstract | Aim of the study: The aim of the study was to determine the excess risk of all-cause and cardiovascular mortality in older people with elevated liver enzymes [alanine transaminase (ALT) and gamma glutamyltransferase (GGT)]. Methods: We utilized data from a large, prospective, population based study of 2061 people aged 50 to 99 years with linkage to a National Death Registry. Participants were categorized as having elevated liver enzymes using standard thresholds (for males, GGT>51 and ALT>40 IU/L, and GGT>33 and ALT>31 IU/L for females). Adjusted Cox proportional hazards models assessed the association of elevated liver enzymes and mortality with long duration follow-up. Results: Over a median follow-up of 10 years (20,145 person years), 701 people died, including 203 (34%) from cardiovascular disease. Cox regression models adjusted for sex, age, smoking, and alcohol intake indicated that people with elevated liver enzymes had an increased risk of all-cause mortality that was modified by age (test for interaction P=0.01). Age-stratified analyses demonstrated no increased risk at younger ages [age 59 y and below; hazard ratio (HR): 0.46; 95% confidence interval, 0.06-3.49], but increased risk with age; age 60 to 69, HR: 1.05 (0.53-2.07), age 70 to 79 years, HR: 1.54 (0.81 to 2.93), and age 80 years and above, HR: 3.53 (1.55 to 8.04). Similarly, the risk of cardiovascular mortality with elevated liver enzymes was also modified by, and increased with age (test for interaction P=0.02); age 70 to 79, HR: 3.15 (1.37 to 7.23), age 80 years and above, HR: 6.86 (2.44 to 19.30). Conclusions: In community-dwelling elderly persons, an elevation in both ALT and GGT are associated with an excess risk of all-cause and cardiovascular mortality which increases with age. | en_AU |
dc.language.iso | en_AU | en_AU |
dc.publisher | Wolters Kluwer | en_AU |
dc.subject | liver enzymes | en_AU |
dc.subject | population | en_AU |
dc.subject | cohort | en_AU |
dc.subject | survival | en_AU |
dc.title | Elevated Liver Enzymes and Mortality in Older Individuals: A Prospective Cohort Study | en_AU |
dc.type | Article | en_AU |
dc.identifier.doi | 10.1097/MCG.0000000000000622 | |
dc.type.pubtype | Post-print | en_AU |
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