Prevalence of elevated alanine transaminase in Australia and its relationship to metabolic risk factors: A cross-sectional study of 9,447 people
Field | Value | Language |
dc.contributor.author | Mahady, Suzanne E | |
dc.contributor.author | Gale, J | |
dc.contributor.author | Macaskill, P | |
dc.contributor.author | Craig, JC | |
dc.contributor.author | George, Jacob | |
dc.date.accessioned | 2017-02-20 | |
dc.date.available | 2018-01-05 | |
dc.date.issued | 2017-01-01 | |
dc.identifier.citation | Prevalence of elevated ALT in Australia and its relationship to metabolic risk factors: a cross sectional study of 9,447 people. Journal of Gastroenterology & Hepatology. 2017;32(1):169-176. doi: 10.1111/jgh.13434. | en_AU |
dc.identifier.uri | http://hdl.handle.net/2123/16384 | |
dc.description | Post-print | en_AU |
dc.description.abstract | BACKGROUND AND AIM: Elevated alanine transaminase (ALT) is a strong predictor of metabolic syndrome, but there are few data from the Australian population. We aimed to determine the prevalence of elevated ALT and association with metabolic risk factors. METHODS: In this cross-sectional study including adult participants (N = 9,447) from a nationwide, population-based survey, we assessed the prevalence of elevated ALT [defined as ≥ 40 IU/L (men) and ≥ 30 IU/L (women) as baseline, and ALT as ≥ 30 IU/L (men) and ≥ 19 IU/L (women) as lower threshold], distribution of metabolic risk factors, and independent predictors of elevated ALT in logistic regression models. Analyses were weighted to the population with population weights. RESULTS: Elevated ALT levels were found in 11.2% of the Australian population. People with elevated ALT were younger (43 vs 46 yrs) with more truncal adiposity (100 vs 91 cm), higher pro-atherogenic lipids and glucose and exercised less (120 vs 160 min per week, P < 0.05 for all analyses). Regression analyses indicated that younger age, male sex, diabetes, triglycerides, apolipoprotein B, and waist circumference were independent predictors of elevated ALT. The population attributable fraction of elevated ALT due to truncal obesity was estimated at 47%. CONCLUSION: These data demonstrate a high prevalence of elevated ALT in the general population that is closely associated with metabolic risk factors. Individuals with elevated ALT should be evaluated for co-existent metabolic disorders. | en_AU |
dc.language.iso | en_AU | en_AU |
dc.publisher | Wiley Online Library | en_AU |
dc.rights | This is the peer reviewed version of the following article: [Prevalence of elevated ALT in Australia and its relationship to metabolic risk factors: a cross sectional study of 9,447 people. Journal of Gastroenterology & Hepatology. 2017;32(1):169-176, which has been published in final form at doi: 10.1111/jgh.13434.]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_AU |
dc.subject | ALT | en_AU |
dc.subject | cross-sectional study | en_AU |
dc.subject | metabolic syndrome | en_AU |
dc.subject | population | en_AU |
dc.title | Prevalence of elevated alanine transaminase in Australia and its relationship to metabolic risk factors: A cross-sectional study of 9,447 people | en_AU |
dc.type | Article | en_AU |
dc.identifier.doi | 10.1111/jgh.13434 |
Associated file/s
Associated collections