Clinical phenotypes associated with impaired response to treatment in children with acute asthma
| Field | Value | Language |
| dc.contributor.author | Minaee, Noviani | |
| dc.date.accessioned | 2016-09-13 | |
| dc.date.available | 2016-09-13 | |
| dc.date.issued | 2016-09-13 | |
| dc.identifier.uri | http://hdl.handle.net/2123/15647 | |
| dc.description | This project is part of a larger study titled “Mechanisms of Acute Viral Respiratory Infection in Children (MAVRIC)”. It is a prospective study of the role of viruses and immunogenetic risk profiles for viral infections. My project's aim is to identify distinct phenotypic groups using cluster analysis and to explore the association between those identified clusters both with asthma candidate genes and with a susceptibility to human rhinovirus. The acute asthma cohort from the MAVRIC study provides a unique opportunity to investigate this research question. | en_AU |
| dc.description.abstract | Asthma comprises inflammation of the airways, characterised by reversible airways obstruction, airway hyper-responsiveness (AHR) and bronchial spasm (Dougherty & Fahy, 2009). Asthma, particularly childhood asthma, is a National Health Priority costing Australia >$606 million annually. First symptoms of asthma usually occur during the first few years of childhood. Of those, a large proportion of children become symptom free by the time they reach school age and the rest continue to develop persistent asthma throughout childhood (Martinez & Vercelli, 2013). This project aims to predict the treatment response by identifying a specific group of children with acute wheezing and asthma who do not respond the treatment well and are likely to relapse and re-present to hospital. The recurrence of hospital presentations was further examined to see whether it is associated with specific asthma phenotypes and potential risk factors. | en_AU |
| dc.language.iso | en_AU | en_AU |
| dc.title | Clinical phenotypes associated with impaired response to treatment in children with acute asthma | en_AU |
| dc.type | Other | en_AU |
| dc.type.pubtype | Pre-print | en_AU |
Associated file/s
Associated collections