|Title:||Maternal body weight and first trimester screening for chromosomal anomalies|
|Authors:||Khambalia, Amina Z|
Roberts, Christine L.
Morris, Jonathan M
body mass index
|Citation:||Khambalia AZ, Roberts CL, Morris JM, Tasevski V, Nassar N. Maternal body weight and first trimester screening for chromosomal anomalies. Australian and New Zealand Journal of Obstetrics and Gynaecology 2014; 54: 490–492.|
|Abstract:||Prenatal risk ratios for Down syndrome adjust for maternal weight because maternal serum 2 biomarker levels decrease with increasing maternal weight. This is accomplished by converting 3 serum biomarker values into a multiple of the expected median (MOM) for women of the same 4 gestational age. Weight is frequently not recorded and the impact of using MOMs not adjusted for 5 weight for calculating risk ratios is unknown. The aim of this study is to examine the effect of 6 missing weight on first trimester Down syndrome risk ratios by comparing risk ratios calculated 7 using weight-unadjusted-and –adjusted MOMs. Findings at the population level indicate that the 8 impact of not adjusting for maternal weight on first trimester screening results for chromosomal 9 anomalies would lead to under-identification of 84 per 10,000 pregnancies.|
|Type of Work:||Article, Letter|
|Type of Publication:||Pre-print|
|Appears in Collections:||Healthy Start to Life|
|Khambalia_2014_ANZJOG_WeightValidation_pre-proof.pdf||216.05 kB||Adobe PDF|
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