Browsing by author "Triccas, James A."
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Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies
Spain, Malcolm; Wong, Joseph K.-H.; Nagalingam, Gayathri; Batten, James M.; Hortle, Elinor; Oehlers, Stefan; Jiang, Xiao Fan; Murage, Hasini E.; Orford, Jack T.; Crisologo, Patrick; Triccas, James A.; Rutledge, Peter J.; Todd, Matthew H.Published 2018-03-20We recently reported the discovery of non-toxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we report exploration of the structure-activity relationship for ...Open AccessArticle -
Discovery of Cyclic Peptide Ligands to the SARS-CoV_2 Spike Protein Using mRNA Display
Norman, Alexander; Franck, Charlotte; Christie, Mary; Hawkins, Paige M. E.; Patel, Karishma; Ashhurst, Anneliese S.; Aggarwal, Anupriya; Low, Jason K. K.; Siddiquee, Rezwan; Ashley, Caroline L.; Steain, Megan; Triccas, James A.; Turville, Stuart; Mackay, Joel P.; Passioura, Toby; Payne, Richard J.Published 2021The COVID-19 pandemic, caused by SARS-CoV-2, has led to substantial morbidity, mortality, and disruption globally. Cellular entry of SARS-CoV-2 is mediated by the viral spike protein, and affinity ligands to this surface ...Article -
High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens
Counoupas, Claudio; Pino, Paco; Stella, Alberto O.; Ashley, Caroline; Lukeman, Hannah; Bhattacharyya, Nayan D.; Tada, Takuya; Anchisi, Stephanie; Metayer, Charles; Martinis, Jacopo; Aggarwal, Anupriya; Dcosta, Belinda M.; Britton, Warwick J.; Kint, Joeri; Wurm, Maria J.; Landau, Nathaniel R.; Steain, Megan; Turville, Stuart G.; Wurm, Florian M.; David, Sunil A.; Triccas, James A.Published 2022Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine that ...Article -
Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependent protection against pulmonary tuberculosis
Counoupas, Claudio; Ferrell, Kia C.; Ashhurst, Anneliese; Bhattacharyya, Nayan D.; Nagalingam, Gayathri; Stewart, Erica L.; Feng, Carl G.; Petrovsky, Nikolai; Britton, Warwick J.; Triccas, James A.Published 2020Abstract The development of effective vaccines against bacterial lung infections requires the induction of protective, pathogen-specific immune responses without deleterious inflammation within the pulmonary environment. ...Article -
Neutralising antibodies against the SARS-CoV-2 Delta variant induced by Alhydroxyquim-II-adjuvanted trimeric spike antigens
Counoupas, Claudio; Pino, Paco; Stella, Alberto O.; Ashley, Caroline; Lukeman, Hannah; Bhattacharyya, Nayan D.; Tada, Takuya; Anchisi, Stephanie; Metayer, Charles; Martinis, Jacopo; Aggarwal, Anupriya; Dcosta, Belinda M.; Kint, Joeri; Wurm, Maria J; Landau, Nathaniel R.; Steain, Megan; Turville, Stuart G; Wurm, Florian M; David, Sunil A.; Triccas, James A.Published 2021ABSTRACT Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine ...Preprint -
Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis
Yu, Mingfeng; Nagalingam, Gayathri; Ellis, Samantha; Martinez, Elena; Sintchenko, Vitali; Spain, Malcolm; Rutledge, Peter J; Todd, Matthew H; Triccas, James A.Published 2016-05-23Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against ...Open AccessArticle
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