Browsing by author "Tebbutt, Niall C"
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Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer
Price, Timothy J; Bruhn, Maressa A; Lee, Chee K; Hardingham, Jennifer E; Townsend, Amanda R; Mann, Kristy P; Simes, John; Weickhardt, Andrew; Wrin, Joseph W; Wilson, Kate; Gebski, Val; van Hazel, Guy; Robinson, Bridget; Cunningham, David; Tebbutt, Niall CPublished 2015-03-05Background: Mutations affecting RAS genes are now established predictive markers of nonresponse to anti-EGFR antibodies in advanced CRC. This analysis assessed the prognostic and predictive impact of extended RAS and PIK3CA ...Open AccessArticle -
The cost effectiveness of bevacizumab when added to capecitabine, with or without mitomycin-C, in first line treatment of metastatic colorectal cancer: results from the Australasian phase III MAX study
Carter, Hannah; Zannino, Diana; Simes, R John; Schofield, Deborah J; Howard, Kirsten; Zalcberg, John R; Price, Timothy J; Tebbutt, Niall CPublished 2015-12-14Background: Based on the clinical data, bevacizumab has been approved in Australia and globally for the treatment of advanced colorectal cancer. However, limited evidence exists for its cost-effectiveness. The purpose of ...Open AccessArticle -
Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer receiving bevacizumab
Price, Timothy J; Hardingham, Jennifer E; Lee, Chee K; Townsend, Amanda R; Wrin, Joseph W; Wilson, Kate; Weickhardt, Andrew; Simes, Robert J; Murone, Carmel; Tebbutt, Niall CPublished 2013-03-01Loss of phosphatase and tensin homologue (PTEN) expression may be prognostic in colorectal cancer (CRC) and may have a correlation with vascular endothelial growth factor (VEGF) expression via hypoxia-inducible factor 1 ...Open AccessArticle -
Single-agent irinotecan or FOLFIRI as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis
Clarke, Stephen; Yip, Sonia; Brown, Chris; Van Hazel, Guy; Ransom, David T; Goldstein, David; Jeffrey, G Mark; Tebbutt, Niall C; Buck, Martin; Lowenthal, Raymond M; Boland, Amy; Gebski, Val; Zalcberg, John; Simes, R JohnPublished 2011-06-10Background Second-line treatment with irinotecan for advanced or metastatic colorectal cancer prolongs survival. It is uncertain whether irinotecan is better administered with 5- fluorouracil or alone in patients previously ...Open AccessArticle
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