Browsing by author "Sutherland, GT"
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A cross-study transcriptional analysis of Parkinson's disease
Sutherland, GT; Matigian, NA; Chalk, AM; Anderson, MJ; Silburn, PA; Mackay-Sim, A; Wells, CA; Mellick, GDPublished 2009-01-01The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer ...Open AccessArticle -
Disease-specific, neurosphere-derived cells as models for brain disorders
Matigian, N; Abrahamsen, G; Sutharsan, R; Cook, AL; Vitale, AM; Nouwens, A; Bellette, B; An, J; Anderson, M; Beckhouse, AG; Bennebroek, M; Cecil, R; Chalk, AM; Cochrane, J; Fan, Y; Féron, F; McCurdy, R; McGrath, JJ; Murrell, W; Perry, C; Raju, J; Ravishankar, S; Silburn, PA; Sutherland, GT; Mahler, S; Mellick, GD; Wood, SA; Sue, CM; Wells, CA; Mackay-Sim, APublished 2010-01-01There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new ...Open AccessArticle -
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
Sutherland, GT; Halliday, GM; Silburn, PA; Mastaglia, FL; Rowe, DB; Boyle, RS; O'Sullivan, JD; Ly, T; Wilton, SD; Mellick, GDPublished 2009-01-01Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the ...Open AccessArticle -
Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease
Lumsden, AL; Rogers, JT; Majd, S; Newman, M; Sutherland, GT; Verdile, G; Lardelli, MPublished 2018-01-01The overwhelming majority of dominant mutations causing early onset familial Alzheimer's disease (EOfAD) occur in only three genes, PSEN1, PSEN2, and APP. An effect-in-common of these mutations is alteration of production ...Open AccessArticle -
Epidemiological Approaches to Understanding the Link Between Type 2 Diabetes and Dementia.
Sutherland, GT; Lim, J; Srikanth, V; Bruce, DGPublished 2017-01-01Diabetes and dementia are two diseases that increased dramatically in most societies in direct proportion to increases in average life expectancy. The two conditions are strongly associated and there is much hope that ...Open AccessArticle -
Evidence supporting oxidative stress in a moderately affected area of the brain in Alzheimer’s disease
Youssef, P; Chami, B; Lim, J; Middleton, T; Sutherland, GT; Witting, PKPublished 2018-08-01The pathogenesis of Alzheimer's disease (AD) remains to be elucidated. Oxidative damage and excessive beta-amyloid oligomers are components of disease progression but it is unclear how these factors are temporally related. ...Open AccessArticle -
Exploiting the potential of molecular profiling in Parkinson's disease: current practice and future probabilities
Mellick, GD; Silburn, PA; Sutherland, GT; Siebert, GAPublished 2010-01-01Parkinson's disease (PD) is a common, heterogeneous syndrome diagnosed clinically by the presence of classical neurological symptoms and the absence of 'red flags' that suggest alternative secondary parkinsonian disorders. ...Open AccessArticle -
Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
Sutherland, GT; Siebert, GA; Newman, JR; Silburn, PA; Boyle, RS; O'Sullivan, JD; Mellick, GDPublished 2009-01-01Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence ...Open AccessArticle -
Human adult neurogenesis across the ages: An immunohistochemical study
Dennis, CV; Suh, LS; Rodriguez, ML; Kril, JJ; Sutherland, GTPublished 2016-01-01AIMS: Neurogenesis in the postnatal human brain occurs in two neurogenic niches; the subventricular zone (SVZ) in the wall of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus. The extent to which ...Open AccessArticle -
Identification of an immune modulation locus utilising a bovine mammary gland infection challenge model
Littlejohn, MD; Turner, SA; Walker, CG; Berry, SD; Tiplady, K; Sherlock, RG; Sutherland, GT; Swift, S; Garrick, D; Lacy-Hulbert, SJ; McDougall, S; Spelman, RJ; Snell, RG; Hillerton, JEPublished 2018-01-01Inflammation of the mammary gland following bacterial infection, commonly known as mastitis, affects all mammalian species. Although the aetiology and epidemiology of mastitis in the dairy cow are well described, the genetic ...Open AccessArticle -
Imaging mass spectrometry of frontal white matter lipid changes in human alcoholics
de la Monte, SM; Kay, J; Yalcin, EB; Kril, JJ; Sheedy, D; Sutherland, GTPublished 2018-01-01BACKGROUND: Chronic alcohol use disorders (AUD) are associated with white matter (WM) degeneration with altered myelin integrity. Matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS) enables ...Open AccessArticle -
Lack of reproducibility in re-evaluating associations between GCH1 polymorphisms and Parkinson's disease and isolated dystonia in an Australian case--control group.
Newman, JR; Todorovic, M; Silburn, PA; Sutherland, GT; Mellick, GDPublished 2014-01-01Open AccessArticle -
N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research.
Morley, KC; Baillie, A; Van Den Brink, W; Chitty, KE; Brady, K; Back, SE; Seth, D; Sutherland, GT; Leggio, L; Haber, PSPublished 2018-01-01Alcoholic liver disease (ALD) is the leading cause of alcohol-related death and one of the most common forms of liver disease. Abstinence from alcohol is crucial to reducing morbidity and mortality associated with the ...Open AccessArticle -
Neuropathology of alcoholism
Sutherland, GT; Sheedy, D; Kril, JJPublished 2014-01-01Chronic alcohol consumption results in structural changes to the brain. In alcoholics without coexisting thiamine deficiency or liver disease this is largely restricted to a loss of white-matter volume. When it occurs, ...Open AccessArticle -
NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease
Cook, AL; Vitale, AM; Ravishankar, S; Matigian, N; Sutherland, GT; Shan, J; Sutharsan, R; Perry, C; Silburn, PA; Mellick, GD; Whitelaw, ML; Wells, CA; Mackay-Sim, A; Wood, SAPublished 2011-01-01BACKGROUND: Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa ...Open AccessArticle -
Optimal Preparation of Formalin Fixed Samples for Peptide Based Matrix Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Workflows.
O'Rourke, MB; Padula, MP; Smith, C; Youssef, P; Cordwell, S; Witting, P; Sutherland, GT; Crossett, BPublished 2018-01-01The use of matrix-assisted laser desorption/ionization, mass spectrometry imaging (MALDI MSI) has rapidly expanded, since this technique analyzes a host of biomolecules from drugs and lipids to N-glycans. Although various ...Open AccessArticle -
Re-investigating the effects of chronic smoking on the pathology of alcohol-related human brain damage
McCorkindale, AN; Sizemova, A; Sheedy, D; Kril, JJ; Sutherland, GTPublished 2018-07-01Both pathological and neuroimaging studies have shown that chronic alcohol abuse causes generalized white matter, but limited gray matter, volume loss. Recent neuroimaging studies suggest that tobacco smoking also causes ...Open AccessArticle
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