Browsing by author "Subbarao, Kanta"
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BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)
Pittet, Laure F; Messina, Nicole L; Gardiner, Kaya; Orsini, Francesca; Abruzzo, Veronica; Bannister, Samantha; Bonten, Marc; Campbell, John L; Croda, Julio; Dalcolmo, Margareth; Elia, Sonja; Germano, Susie; Goodall, Casey; Gwee, Amanda; Jamieson, Tenaya; Jardim, Bruno; Kollmann, Tobias R; Guimarães Lacerda, Marcus Vinícius; Lee, Katherine J; Legge, Donna; Lucas, Michaela; Lynn, David J; McDonald, Ellie; Manning, Laurens; Munns, Craig F; Perrett, Kirsten P; Prat Aymerich, Cristina; Richmond, Peter; Shann, Frank; Sudbury, Eva; Villanueva, Paola; Wood, Nicholas J; Lieschke, Katherine; Subbarao, Kanta; Davidson, Andrew; Curtis, Nigel;Published 2021INTRODUCTION: BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging pathogens. As a readily available, inexpensive intervention that has a well-established ...Article -
BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection
Mills, Richard J.; Humphrey, Sean J.; Fortuna, Patrick RJ.; Lor, Mary; Foster, Simon R.; Quaife-Ryan, Gregory A.; Johnston, Rebecca L.; Dumenil, Troy; Bishop, Cameron; Ruraraju, Rajeev; Rawle, Daniel J.; Le, Thuy; Zhao, Wei; Lee, Leo; Mackenzie-Kludas, Charley; Mehdiabadi, Neda R.; Halliday, Christopher; Gilham, Dean; Fu, Li; Nicholls, Stephen J.; Johansson, Jan; Sweeney, Michael; Wong, Norman C.W.; Kulikowski, Ewelina; Sokolowski, Kamil A.; Tse, Brian W.C.; Devilée, Lynn; Voges, Holly K.; Reynolds, Liam T.; Krumeich, Sophie; Mathieson, Ellen; Abu-Bonsrah, Dad; Karavendzas, Kathy; Griffen, Brendan; Titmarsh, Drew; Elliott, David A.; McMahon, James; Suhrbier, Andreas; Subbarao, Kanta; Porrello, Enzo R.; Smyth, Mark J.; Engwerda, Christian R.; MacDonald, Kelli PA.; Bald, Tobias; James, David E.; Hudson, James E.Published 2021Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined, but could be direct cardiac infection and/or inflammation-induced dysfunction. To identify mechanisms ...Article -
Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19
Wheatley, Adam K.; Juno, Jennifer A.; Wang, Jing J.; Selva, Kevin J.; Reynaldi, Arnold; Tan, Hyon-Xhi; Lee, Wen Shi; Wragg, Kathleen M.; Kelly, Hannah G.; Esterbauer, Robyn; Davis, Samantha K.; Kent, Helen E.; Mordant, Francesca L.; Schlub, Timothy E.; Gordon, David L.; Khoury, David S.; Subbarao, Kanta; Cromer, Deborah; Gordon, Tom P.; Chung, Amy W.; Davenport, Miles P.; Kent, Stephen J.Published 2021The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we show a comprehensive profile of antibody, B cell and T cell dynamics over time in a cohort ...Article -
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
Koutsakos, Marios; Rowntree, Louise C; Hensen, Luca; Chua, Brendon Y; van de Sandt, Carolien E; Habel, Jennifer R; Zhang, Wuji; Jia, Xiaoxiao; Kedzierski, Lukasz; Ashhurst, Thomas M; Putri, Givanna H; Marsh-Wakefield, Felix; Read, Mark N; Edwards, Davis N; Clemens, E Bridie; Wong, Chinn Yi; Mordant, Francesca L; Juno, Jennifer A; Amanat, Fatima; Audsley, Jennifer; Holmes, Natasha E; Gordon, Claire L; Smibert, Olivia C; Trubiano, Jason A; Hughes, Carly M; Catton, Mike; Denholm, Justin T; Tong, Steven Y C; Doolan, Denise L; Kotsimbos, Tom C; Jackson, David C; Krammer, Florian; Godfrey, Dale I; Chung, Amy W; King, Nicholas J C; Lewin, Sharon R; Wheatley, Adam K; Kent, Stephen J; Subbarao, Kanta; McMahon, James; Thevarajan, Irani; Nguyen, Thi H O; Cheng, Allen C; Kedzierska, KatherinePublished 2021SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or convalescent time points, up to 102 days after symptom ...Article -
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.
Khoury, David S; Cromer, Deborah; Reynaldi, Arnold; Schlub, Timothy E; Wheatley, Adam K; Juno, Jennifer A; Subbarao, Kanta; Kent, Stephen J; Triccas, James A; Davenport, Miles PPublished 2021Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the future deployment of vaccines. To address this, we analyzed the relationship between in vitro ...Article -
Vaccines for older adults
Cunningham, Anthony L; McIntyre, Peter; Subbarao, Kanta; Booy, Robert; Levin, Myron JPublished 2021The proportion of the global population aged 65 and older is rapidly increasing. Infections in this age group, most recently with SARS-CoV-2, cause substantial morbidity and mortality. Major improvements have been made in ...Article -
What level of neutralising antibody protects from COVID-19?
Khoury, David S; Cromer, Deborah; Reynaldi, Arnold; Schlub, Timothy E; Wheatley, Adam K; Juno, Jennifer A; Subbarao, Kanta; Kent, Stephen J; Triccas, James A; Davenport, Miles PPublished 2021Both previous infection and vaccination have been shown to provide potent protection from COVID-19. However, there are concerns that waning immunity and viral variation may lead to a loss of protection over time. Predictive ...Preprint
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