Browsing by author "Snelling, Thomas"
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ASCOT ADAPT study of COVID-19 therapeutics in hospitalised patients: an international multicentre adaptive platform trial
Denholm, Justin T; Venkatesh, Balasubramanian; Davis, Joshua; Bowen, Asha C.; Hammond, Naomi E; Jha, Vivekanand; McPhee, Grace; McQuilten, Zoe; O'Sullivan, Matthew VN; Paterson, David; Price, David; Rees, Megan; Roberts, Jason; Jones, Mark; Totterdell, James; Snelling, Thomas; Trask, Nanette; Morpeth, Susan; Tong, Steven YCPublished 2022Background SARS-CoV-2 infection is associated with a significant risk of hospitalisation, death, and prolonged impact on quality of life. Evaluation of new treatment options and optimising therapeutic management of people ...Preprint -
The Australasian COVID-19 Trial (ASCOT) to assess clinical outcomes in hospitalised patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care: A structured summary of a study protocol for a randomised controlled trial
Denholm, Justin T.; Davis, Joshua; Paterson, David; Roberts, Jason; Morpeth, Susan; Snelling, Thomas; Zentner, Dominica; Rees, Megan; O'Sullivan, Matthew; Price, David; Bowen, Asha; Tong, Steven Y. C.Published 2020Objectives: To determine if lopinavir/ritonavir +/- hydroxychloroquine will reduce the proportion of participants who survive without requiring ventilatory support, 15 days after enrolment, in adult participants with ...Article -
Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial
Hockham, Carinna; Kotwal, Sradha; Wilcox, Arlen; Bassi, Abhinav; McGree, James; Pollock, Carol; Burrell, Louise M.; Bathla, Nikita; Kunigari, Mallikarjuna; Rathore, Vinay; John, Michael; Lin, Enmoore; Jenkins, Christine; Ritchie, Angus; McLachlan, Andrew; Snelling, Thomas; Jones, Mark; Jha, Vivekanand; Jardine, Meg;Published 2021BackgroundSARS-CoV-2 binds to membrane-bound angiotensin-converting enzyme 2 (ACE2) which may result in downregulation of membrane-bound ACE2. ACE2 is a key regulator of the renin-angiotensin system (RAS) and is responsible ...Article
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