Browsing by author "Simes, John"
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Aspirin for preventing venous thromboembolism [commentary]
Brighton, Timothy A; Eikelboom, John W; Simes, JohnPublished 2013-02-21Open AccessArticle, Letter -
Association of Contemporary Sensitive Troponin I Levels at Baseline and Change at 1 Year With Long-Term Coronary Events Following Myocardial Infarction or Unstable Angina : Results From the LIPID Study (Long-Term Intervention With Pravastatin in Ischaemic Disease)
White, Harvey D; Tonkin, Andrew; Simes, John; Mann, Kristy; Thompson, Peter; Colquhoun, David; West, Malcolm; Nestel, Paul; Sullivan, David; Keech, Anthony C; Hunt, David; Blankenberg, StefanPublished 2013-09-30Objectives This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects ...Open AccessArticle -
Changes in Lipoprotein-Associated Phospholipase A2 Activity Predict Coronary Events and Partly Account for the Treatment Effect of Pravastatin: Results From the Long-term Intervention with Pravastatin in Ischemic Disease Study
White, Harvey D; Simes, John; Stewart, Ralph AH; Blankenberg, Stefan; Barnes, Elizabeth H; Marschner, Ian C; Thompson, Peter; West, Malcolm; Zeller, Tanja; Colquhoun, David M; Nestel, Paul; Keech, Anthony C; Sullivan, David R; Hunt, David; Tonkin, AndrewPublished 2013-10-01Background-—Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are associated with coronary heart disease (CHD) in healthy individuals and in patients who have had ischemic events. Methods and Results-—The Long-term ...Open AccessArticle -
Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer
Price, Timothy J; Bruhn, Maressa A; Lee, Chee K; Hardingham, Jennifer E; Townsend, Amanda R; Mann, Kristy P; Simes, John; Weickhardt, Andrew; Wrin, Joseph W; Wilson, Kate; Gebski, Val; van Hazel, Guy; Robinson, Bridget; Cunningham, David; Tebbutt, Niall CPublished 2015-03-05Background: Mutations affecting RAS genes are now established predictive markers of nonresponse to anti-EGFR antibodies in advanced CRC. This analysis assessed the prognostic and predictive impact of extended RAS and PIK3CA ...Open AccessArticle -
Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis
Fogarty, Michael; Osborn, David A; Askie, Lisa; Seidler, Anna Lene; Hunter, Kylie; Lui, Kei; Simes, John; Tarnow-Mordi, WilliamPublished 2017Background: The effects of delayed cord clamping of the umbilical cord in preterm infants are unclear. Objective: We sought to compare the effects of delayed vs early cord clamping on hospital mortality (primary outcome) ...Open AccessArticle -
Effects of fenofibrate on cardiovascular events in patients with diabetes, with and without prior cardiovascular disease: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Tonkin, Andrew; Hunt, David; Voysey, Merryn; Kesäniemi, Antero; Hamer, Andrew; Waites, Jonathon; Maher, Leo; Mann, Stewart; Glasziou, Paul; Forder, Peta; Simes, John; Keech, AnthonyPublished 2012-02-01Background In the FIELD study, comparison of the effect of fenofibrate on cardiovascular disease (CVD) between those with prior CVD and without was a prespecified subgroup analysis. Methods The effects of fenofibrate on ...Open AccessArticle -
Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials
Cholesterol Treatment Trialists’ (CTT) Collaboration; Fulcher, Jordan; O'Connell, Rachel; Voysey, Merryn; Emberson, Jonathan; Blackwell, Lisa; Mihaylova, Borislava; Simes, John; Collins, Rory; Kirby, Adrienne; Colhoun, Helen; Braunwald, Eugene; LaRosa, John; Pedersen, TR; Tonkin, Andrew; Davis, Barry; Slright, Peter; Franzosi, Maria Grazia; Baigent, Colin; Keech, AnthonyPublished 2015-01-09Background Whether statin therapy is as effective in women as in men is debated, especially for primary prevention. We undertook a meta-analysis of statin trials in the Cholesterol Treatment Trialists' (CTT) Collaboration ...Open AccessArticle -
Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances
Orkin, Aaron M.; Gill, Peter J.; Ghersi, Davina; Campbell, Lisa; Sugarman, Jeremy; Emsley, Richard; Steg, Philippe Gabriel; Weijer, Charles; Simes, John; Rombey, Tanja; Williams, Hywel C.; Wittes, Janet; Moher, David; Richards, Dawn P.; Kasamon, Yvette; Getz, Kenneth; Hopewell, Sally; Dickersin, Kay; Wu, Taixiang; Ayala, Ana Patricia; Schulz, Kenneth F.; Calleja, Sabine; Boutron, Isabelle; Ross, Joseph S.; Golub, Robert M.; Khan, Karim M.; Mulrow, Cindy; Siegfried, Nandi; Heber, Joerg; Lee, Naomi; Kearney, Pamela Reed; Wanyenze, Rhoda K.; Hróbjartsson, Asbjørn; Williams, Rebecca; Bhandari, Nita; Jüni, Peter; Chan, An-Wen; Orkin, Aaron M.; Gill, Peter J.; Ghersi, Davina; Campbell, Lisa; Sugarman, Jeremy; Emsley, Richard; Steg, Philippe Gabriel; Weijer, Charles; Simes, John; Rombey, Tanja; Williams, Hywel C.; Wittes, Janet; Moher, David; Richards, Dawn P.; Kasamon, Yvette; Getz, Kenneth; Hopewell, Sally; Dickersin, Kay; Wu, Taixiang; Ayala, Ana Patricia; Schulz, Kenneth F.; Calleja, Sabine; Boutron, Isabelle; Ross, Joseph S.; Golub, Robert M.; Khan, Karim M.; Mulrow, Cindy; Siegfried, Nandi; Heber, Joerg; Lee, Naomi; Kearney, Pamela Reed; Wanyenze, Rhoda K.; Hróbjartsson, Asbjørn; Williams, Rebecca; Bhandari, Nita; Jüni, Peter; Chan, An-Wen; Kiermer, Veronique; Corrigan-Curay, Jacqueline; Concato, JohnPublished 2021Importance: Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, and analytical challenges that can potentially compromise the validity of findings. ...Article -
Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy
Emberson, Jonathan R; Kearney, Patricia M; Blackwell, Lisa; Newman, Connie; Reith, Christina; Bhala, Neeraj; Holland, Lisa; Peto, Richard; Keech, Anthony; Collins, Rory; Simes, John; Baigent, ColinPublished 2012-01-19Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL ...Open AccessArticle -
Low-dose aspirin for preventing recurrent venous thromboembolism
Brighton, Timothy A; Eikelboom, John W; Gibbs, Harry; Hague, Wendy; Xavier, Denis; Diaz, Rafael; Kirby, Adrienne; Simes, JohnPublished 2012-11-22Patients who have had a first episode of unprovoked venous thromboembolism have a high risk of recurrence after anticoagulants are discontinued. Aspirin may be effective in preventing a recurrence of venous thromboembolism. ...Open AccessArticle -
Midregional proadrenomedullin and its change predicts recurrent major coronary events and heart failure in stable coronary heart disease patients: The LIPID study
Funke-Kaiser, Anne; Mann, Kristy; Colquhoun, David; Zeller, Tanja; Hunt, David; Simes, John; Sullivan, David; Sydow, Karsten; West, Malcolm; White, Harvey; Blankenberg, Stefan; Tonkin, Andrew MPublished 2014-01-24Background: Biomarkers may contribute to risk stratification in coronary heart disease (CHD). We examined whether plasma midregional proadrenomedullin (MR-proADM) concentration at baseline and its change over one year ...Open AccessArticle -
Neuro-oncology practices in Australia: a Cooperative Group for Neuro-Oncology patterns of care study
Chen, James Y; Hovey, Elizabeth; Rosenthal, Mark; Livingstone, Ann; Simes, JohnPublished 2013-05-29AIMS: To provide data on the patterns of care in neuro-oncology practices at Australian cancer centres over the previous 12-month period. METHODS: A 5-page questionnaire was sent to Cooperative Trials Group for Neuro-Oncology ...Open AccessArticle -
Oral cannabinoid-rich THC/CBD cannabis extract for secondary prevention of chemotherapy-induced nausea and vomiting: a study protocol for a pilot and definitive randomised double-blind placebo-controlled trial (CannabisCINV)
Mersiades, Antony J; Tognela, Annette; Haber, Paul S; Stockler, Martin; Lintzeris, Nicholas; Simes, John; McGregor, Iain; Olver, Ian; Allsop, David J; Gedye, Craig; Kirby, Adrienne C.; Morton, Rachael L; Fox, Peter; Clarke, Stephen; Briscoe, Karen; Aghmesheh, Morteza; Wong, Nicole; Walsh, Anna; Hahn, Carmel; Grimison, PeterPublished 2018Introduction Chemotherapy-induced nausea and vomiting (CINV) remains an important issue for patients receiving chemotherapy despite guideline-consistent antiemetic therapy. Trials using delta-9-tetrahydrocannabinol-rich ...Open AccessArticle -
Phase II trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy
Ananda, Sumitra; Nowak, Anna; Cher, Lawrence; Dowling, Anthony; Brown, Chris; Simes, John; Rosenthal, Mark APublished 2011-08-02Concurrent and post-radiotherapy temozolomide (T) significantly improves survival in patient with newly diagnosed glioblastoma multiforme. We aimed to assess the activity of the combination of T and pegylated liposomal ...Open AccessArticle -
The Symptom Monitoring with Feedback Trial (SWIFT): protocol for a registry‑based cluster randomised controlled trial in haemodialysis
Greenham, Lavern; Bennett, Paul N.; Dansie, Kathryn; Viecelli, Andrea K.; Jesudason, Shilpanjali; Mister, Rebecca; Smyth, Brendan; Westall, Portia; Herzog, Samuel; Brown, Chris; Handke, William; Palmer, Suetonia C.; Caskey, Fergus J.; Couchoud, Cecile; Simes, John; McDonald, Stephen P.; Morton, Rachael L.Published 2022Background Kidney failure prevalence is increasing worldwide. Haemodialysis, peritoneal dialysis or kidney transplantation are undertaken to extend life with kidney failure. People receiving haemodialysis commonly experience ...Open AccessArticle -
Systematic Review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol
Seidler, Anna Lene; Duley, Lelia; Katheria, Anup C; De Paco Matallana, Catalina; Dempsey, Eugene; Rabe, Heike; Kattwinkel, John; Mercer, Judith; Josephsen, Justin; Fairchild, Karen; Andersson, Ola; Hosono, Shigeharu; Sundaram, Venkataseshan; Datta, Vikram; El-Naggar, Walid; Tarnow-Mordi, William; Debray, Thomas; Hooper, Stuart B; Kluckow, Martin; Polglase, Graeme; Davis, Peter; Montgomery, Alan; Hunter, Kylie E; Barba, Angie; Simes, John; Askie, LisaPublished 2020Introduction Timing of cord clamping and other cord management strategies may improve outcomes at preterm birth. However, it is unclear whether benefits apply to all preterm subgroups. Previous and current trials compare ...Open AccessArticle
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