Browsing by author "Oun, Rabbab"
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A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol
Oun, Rabbab; Plumb, Jane; Wheate, NialPublished 2014-02-18The anticancer drug cisplatin was encapsulated within the cucurbit[7]uril macrocycle to form the host-guest complex: cisplatin@CB[7]. This was then incorporated into gelatin and 0–4% w/v polyvinyl alcohol (PVA)- based ...Open AccessArticle -
Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect
Plumb, Jane A.; Venugopal, Balaji; Oun, Rabbab; Gomez-Roman, Natividad; Kawazoe, Yoshiyuki; Venkataramanan, Natarajan Sathiyamoorthy; Wheate, Nial J.Published 2012-04-18The cucurbit[n]uril (CB[n]) family of macrocycles has been shown to have potential in drug delivery where they are able to provide physical and chemical stability to drugs, improve drug solubility, control drug release and ...Open AccessArticle -
The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles
Oun, Rabbab; Floriano, Rafael S.; Isaacs, Lyle; Rowan, Edward G.; Wheate, Nial J.Published 2014-01-01Open AccessArticle -
The status of platinum anticancer drugs in the clinic and in clinical trials
Wheate, Nial J.; Walker, Shonagh; Craig, Gemma E.; Oun, RabbabPublished 2010-06-30Since its approval in 1979 cisplatin has become an important component in chemotherapy regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as lymphomas, myelomas and melanoma. Unfortunately ...Open AccessArticle -
The status of platinum anticancer drugs in the clinic and in clinical trials
Wheate, Nial J.; Walker, Shonagh; Craig, Gemma E.; Oun, RabbabPublished 2010-01-01Since its approval in 1979 cisplatin has become an important component in chemotherapy regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as lymphomas, myelomas and melanoma. Unfortunately ...Open AccessArticle
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