• Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity 

      Zhang, Wuji; Chua, Brendon Y.; Selva, Kevin J.; Kedzierski, Lukasz; Ashhurst, Thomas M.; Haycroft, Ebene R.; Shoffner, Suzanne K.; Hensen, Luca; Boyd, David F.; James, Fiona; Mouhtouris, Effie; Kwong, Jason C.; Chua, Kyra Y. L.; Drewett, George; Copaescu, Ana; Dobson, Julie E.; Rowntree, Louise C.; Habel, Jennifer R.; Allen, Lilith F.; Koay, Hui-Fern; Neil, Jessica A.; Gartner, Matthew; Lee, Christina Y.; Andersson, Patiyan; Seemann, Torsten; Sherry, Norelle L.; Amanat, Fatima; Krammer, Florian; Londrigan, Sarah L.; Wakim, Linda M.; King, Nicholas J.C.; Godfrey, Dale I.; Mackay, Laura K.; Thomas, Paul G.; Nicholson, Suellen; Arnold, Kelly B.; Chung, Amy W.; Holmes, Natasha E.; Smibert, Olivia C.; Trubiano, Jason A.; Gordon, Claire L.; Nguyen, Thi H.O.; Kedzierska, Katherine
      Published 2021
      ABSTRACT Although the respiratory tract is the primary site of SARS-CoV-2 infection and the ensuing immunopathology, respiratory immune responses are understudied and urgently needed to understand mechanisms underlying ...
      Preprint
    • SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity 

      Zhang, Wuji; Chua, Brendon Y.; Selva, Kevin J.; Kedzierski, Lukasz; Ashhurst, Thomas M.; Haycroft, Ebene R.; Shoffner-Beck, Suzanne K.; Hensen, Luca; Boyd, David F.; James, Fiona; Mouhtouris, Effie; Kwong, Jason C.; Chua, Kyra Y. L.; Drewett, George; Copaescu, Ana; Dobson, Julie E.; Rowntree, Louise C.; Habel, Jennifer R.; Allen, Lilith F.; Koay, Hui-Fern; Neil, Jessica A.; Gartner, Matthew J.; Lee, Christina Y.; Andersson, Patiyan; Khan, Sadid F.; Blakeway, Luke; Wisniewski, Jessica; McMahon, James H.; Vine, Erica E.; Cunningham, Anthony L.; Audsley, Jennifer; Thevarajan, Irani; Seemann, Torsten; Sherry, Norelle L.; Amanat, Fatima; Krammer, Florian; Londrigan, Sarah L.; Wakim, Linda M.; King, Nicholas J. C.; Godfrey, Dale I.; Mackay, Laura K.; Thomas, Paul G.; Nicholson, Suellen; Arnold, Kelly B.; Chung, Amy W.; Holmes, Natasha E.; Smibert, Olivia C.; Trubiano, Jason A.; Gordon, Claire L.; Nguyen, Thi H. O.; Kedzierska, Katherine
      Published 2022
      Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune components in longitudinal blood and respiratory ...
      Article