Browsing by author "Mellick, GD"
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A cross-study transcriptional analysis of Parkinson's disease
Sutherland, GT; Matigian, NA; Chalk, AM; Anderson, MJ; Silburn, PA; Mackay-Sim, A; Wells, CA; Mellick, GDPublished 2009-01-01The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer ...Open AccessArticle -
Disease-specific, neurosphere-derived cells as models for brain disorders
Matigian, N; Abrahamsen, G; Sutharsan, R; Cook, AL; Vitale, AM; Nouwens, A; Bellette, B; An, J; Anderson, M; Beckhouse, AG; Bennebroek, M; Cecil, R; Chalk, AM; Cochrane, J; Fan, Y; Féron, F; McCurdy, R; McGrath, JJ; Murrell, W; Perry, C; Raju, J; Ravishankar, S; Silburn, PA; Sutherland, GT; Mahler, S; Mellick, GD; Wood, SA; Sue, CM; Wells, CA; Mackay-Sim, APublished 2010-01-01There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new ...Open AccessArticle -
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
Sutherland, GT; Halliday, GM; Silburn, PA; Mastaglia, FL; Rowe, DB; Boyle, RS; O'Sullivan, JD; Ly, T; Wilton, SD; Mellick, GDPublished 2009-01-01Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the ...Open AccessArticle -
Exploiting the potential of molecular profiling in Parkinson's disease: current practice and future probabilities
Mellick, GD; Silburn, PA; Sutherland, GT; Siebert, GAPublished 2010-01-01Parkinson's disease (PD) is a common, heterogeneous syndrome diagnosed clinically by the presence of classical neurological symptoms and the absence of 'red flags' that suggest alternative secondary parkinsonian disorders. ...Open AccessArticle -
Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
Sutherland, GT; Siebert, GA; Newman, JR; Silburn, PA; Boyle, RS; O'Sullivan, JD; Mellick, GDPublished 2009-01-01Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence ...Open AccessArticle -
Lack of reproducibility in re-evaluating associations between GCH1 polymorphisms and Parkinson's disease and isolated dystonia in an Australian case--control group.
Newman, JR; Todorovic, M; Silburn, PA; Sutherland, GT; Mellick, GDPublished 2014-01-01Open AccessArticle -
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
Krüger, R; Sharma, M; Riess, O; Gasser, T; Van Broeckhoven, C; Theuns, J; Aasly, J; Annesi, G; Bentivoglio, AR; Brice, A; Djarmati, A; Elbaz, A; Farrer, M; Ferrarese, C; Gibson, JM; Hadjigeorgiou, GM; Hattori, N; Ioannidis, JP; Jasinska-Myga, B; Klein, C; Lambert, JC; Lesage, S; Lin, JJ; Lynch, T; Mellick, GD; de Nigris, F; Opala, G; Prigione, A; Quattrone, A; Ross, OA; Satake, W; Silburn, PA; Tan, EK; Toda, T; Tomiyama, H; Wirdefeldt, K; Wszolek, Z; Xiromerisiou, G; Maraganore, DMPublished 2011-01-01High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common ...Open AccessArticle -
NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease
Cook, AL; Vitale, AM; Ravishankar, S; Matigian, N; Sutherland, GT; Shan, J; Sutharsan, R; Perry, C; Silburn, PA; Mellick, GD; Whitelaw, ML; Wells, CA; Mackay-Sim, A; Wood, SAPublished 2011-01-01BACKGROUND: Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa ...Open AccessArticle
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