Now showing items 1-8 of 8

    • A cross-study transcriptional analysis of Parkinson's disease 

      Sutherland, GT; Matigian, NA; Chalk, AM; Anderson, MJ; Silburn, PA; Mackay-Sim, A; Wells, CA; Mellick, GD (PloS one, 2009)
      The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer ...
    • Disease-specific, neurosphere-derived cells as models for brain disorders 

      Matigian, N; Abrahamsen, G; Sutharsan, R; Cook, AL; Vitale, AM; Nouwens, A; Bellette, B; An, J; Anderson, M; Beckhouse, AG; Bennebroek, M; Cecil, R; Chalk, AM; Cochrane, J; Fan, Y; Féron, F; McCurdy, R; McGrath, JJ; Murrell, W; Perry, C; Raju, J; Ravishankar, S; Silburn, PA; Sutherland, GT; Mahler, S; Mellick, GD; Wood, SA; Sue, CM; Wells, CA; Mackay-Sim, A (Disease models & mechanisms, 2010)
      There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new ...
    • Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? 

      Sutherland, GT; Halliday, GM; Silburn, PA; Mastaglia, FL; Rowe, DB; Boyle, RS; O'Sullivan, JD; Ly, T; Wilton, SD; Mellick, GD (Movement disorders : official journal of the Movement Disorder Society, 2009)
      Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the ...
    • Exploiting the potential of molecular profiling in Parkinson's disease: current practice and future probabilities 

      Mellick, GD; Silburn, PA; Sutherland, GT; Siebert, GA (Expert review of molecular diagnostics, 2010)
      Parkinson's disease (PD) is a common, heterogeneous syndrome diagnosed clinically by the presence of classical neurological symptoms and the absence of 'red flags' that suggest alternative secondary parkinsonian disorders. ...
    • Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease 

      Sutherland, GT; Siebert, GA; Newman, JR; Silburn, PA; Boyle, RS; O'Sullivan, JD; Mellick, GD (Movement disorders : official journal of the Movement Disorder Society, 2009)
      Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence ...
    • Lack of reproducibility in re-evaluating associations between GCH1 polymorphisms and Parkinson's disease and isolated dystonia in an Australian case--control group. 

      Newman, JR; Todorovic, M; Silburn, PA; Sutherland, GT; Mellick, GD (Parkinsonism & related disorders, 2014)
    • A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease 

      Krüger, R; Sharma, M; Riess, O; Gasser, T; Van Broeckhoven, C; Theuns, J; Aasly, J; Annesi, G; Bentivoglio, AR; Brice, A; Djarmati, A; Elbaz, A; Farrer, M; Ferrarese, C; Gibson, JM; Hadjigeorgiou, GM; Hattori, N; Ioannidis, JP; Jasinska-Myga, B; Klein, C; Lambert, JC; Lesage, S; Lin, JJ; Lynch, T; Mellick, GD; de Nigris, F; Opala, G; Prigione, A; Quattrone, A; Ross, OA; Satake, W; Silburn, PA; Tan, EK; Toda, T; Tomiyama, H; Wirdefeldt, K; Wszolek, Z; Xiromerisiou, G; Maraganore, DM (Neurobiology of aging, 2011)
      High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common ...
    • NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease 

      Cook, AL; Vitale, AM; Ravishankar, S; Matigian, N; Sutherland, GT; Shan, J; Sutharsan, R; Perry, C; Silburn, PA; Mellick, GD; Whitelaw, ML; Wells, CA; Mackay-Sim, A; Wood, SA (PloS one, 2011)
      BACKGROUND: Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa ...