Browsing by author "McGowan, Sheena"
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Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine
Malins, Lara R.; Mitchell, Nicholas J.; McGowan, Sheena; Payne, Richard J.Published 2015-09-01Despite the unique chemical properties of selenocysteine (Sec), ligation at Sec is an under‐utilized methodology for protein synthesis. We describe herein an unprecedented protocol for the conversion of Sec to serine (Ser) ...Open AccessArticle -
Synthesis of Gallinamide A Analogues as Potent Falcipain Inhibitors and Antimalarials
Conroy, Trent; Guo, Jin T.; Elias, Nabiha; Cergol, Katie M.; Gut, Jiri; Legac, Jennifer; Khatoon, Lubna; Liu, Yang; McGowan, Sheena; Rosenthal, Philip J.; Hunt, Nicholas H.; Payne, Richard J.Published 2014-11-20Analogues of the natural product gallinamide A were prepared to elucidate novel inhibitors of the falcipain cysteine proteases. Analogues exhibited potent inhibition of falcipain-2 (FP-2) and falcipain-3 (FP-3) and of the ...Open AccessArticle
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