Browsing by author "Liu, Xuyu"
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Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics
Watson, Emma E; Liu, Xuyu; Thompson, Robert E; Ripoll-Rozada, Jorge; Wu, Mike; Alwis, Imala; Gori, Alessandro; Loh, Choy-Theng; Parker, Benjamin L; Otting, Gottfried; Jackson, Shaun; Pereira, Pedro José Barbosa; Payne, Richard J.Published 2018-04-11The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the ...Open AccessArticle -
Rapid Additive-Free Selenocystine–Selenoester Peptide Ligation
Mitchell, Nicholas J.; Malins, Lara R.; Liu, Xuyu; Thompson, Robert E.; Chan, Bun; Radom, Leo; Payne, Richard J.Published 2015-10-21We describe an unprecedented reaction between peptide selenoesters and peptide dimers bearing N-terminal selenocystine that proceeds in aqueous buffer to afford native amide bonds without the use of additives. The ...Open AccessArticle -
Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library To Interrogate HIV Binding and Entry
Liu, Xuyu; Malins, Lara R.; Roche, Michael; Sterjovski, Jasminka; Duncan, Renee; Garcia, Mary L.; Barnes, Nadine C,; Anderson, David A.; Stone, Martin J.; Gorry, Paul R.; Payne, Richard J.Published 2014-06-25Tyrosine (Tyr) sulfation is a common post-translational modification that is implicated in a variety of important biological processes, including the fusion and entry of human immunodeficiency virus type-1 (HIV-1). A number ...Open AccessArticle -
Strategies for the Synthesis of Sulfopeptides and Sulfoproteins as Therapeutic Leads
Liu, XuyuPublished 2016-06-09Tyrosine sulfation is a common post-translational modification (PTM) in multicellular organisms and implicated in numerous physiological and pathological processes occurring in animals. However, the understanding and study ...USyd AccessThesis -
Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry
Thompson, Robert E.; Liu, Xuyu; Alonso-Garcia, Noelia; Pereira, Pedro Jose Barbosa; Jolliffe, Katrina A.; Payne, Richard J.Published 2014-05-15Native chemical ligation followed by desulfurization is a powerful strategy for the assembly of proteins. Here we describe the development of a high-yielding, one-pot ligation−desulfurization protocol that uses ...Open AccessArticle -
Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors
Thompson, Robert E.; Liu, Xuyu; Ripoll-Rozada, Jorge; Alonso-Garcia, Noelia; Parker, Benjamin L.; Pereira, Pedro Jose Barbosa; Payne, Richard J.Published 2017-03-20Madanin-1 and chimadanin are two small cysteine-free thrombin inhibitors that facilitate blood feeding in the tick Haemaphysalis longicornis. Here, we report a post-translational modification—tyrosine sulfation—of these ...Open AccessArticle
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