Browsing by author "Davey, Ross"
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A 39 kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome
Stordal, Britta; Davey, RossPublished 2008-02-19Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ...Open AccessArticle -
ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair
Stordal, Britta; Davey, RossPublished 2008-06-25Background: The H69CIS200 and H69OX400 cell lines are novel models of low- level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the ...Open AccessArticle -
Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review
Stordal, Britta; Pavlakis, Nick; Davey, RossPublished 2007-01-01Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of ...Open AccessArticle -
Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
Stordal, Britta K; Davey, Mary W; Davey, RossPublished 2006-01-01Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant ...Open AccessArticle -
Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest
Stordal, Britta; Davey, RossPublished 2009-01-01The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small-cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin and 400 ng/ml oxaliplatin, ...Open AccessBook chapter -
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship
Stordal, Britta; Pavlakis, Nick; Davey, RossPublished 2007-01-01We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance. Medline was searched for 1) cell models of acquired drug ...Open AccessArticle -
Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy.
Stordal, Britta; Pavlakis, Nick; Davey, RossPublished 2009-01-01Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer. Methods: Medline was searched for 1) Cell models of ...Open AccessBook chapter
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