Browsing by author "Connor, Mark"
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A Continuous, Fluorescence-based Assay of µ-Opioid Receptor Activation in AtT-20 Cells
Knapman, Alisa; Santiago, Marina; Du, Yan Ping; Bennallack, Philip R.; Christie, Macdonald J.; Connor, MarkPublished 2013-03-01Opioids are widely prescribed analgesics, but their use is limited due to development of tolerance and addiction, as well as high variability in individual response. The development of improved opioid analgesics requires ...Open AccessArticle -
β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons
Connor, Mark; Bagley, Elena E.; Chieng, Billy C.; Christie, Macdonald J.Published 2015-01-01BACKGROUND AND PURPOSE: Tolerance to the behavioural effects of morphine is blunted in β-arrestin-2 knockout mice, but opioid withdrawal is largely unaffected. The cellular mechanisms of tolerance have been studied in some ...Open AccessArticle
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