Browsing by author "Christ, Daniel"
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Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19
Khoo, Weng Hua; Jackson, Katherine; Phetsouphanh, Chansavath; Zaunders, John J.; Alquicira-Hernandez, José; Yazar, Seyhan; Ruiz-Diaz, Stephanie; Singh, Mandeep; Dhenni, Rama; Kyaw, Wunna; Tea, Fiona; Merheb, Vera; Lee, Fiona X. Z.; Burrell, Rebecca; Howard-Jones, Annaleise; Koirala, Archana; Zhou, Li; Yuksel, Aysen; Catchpoole, Daniel R.; Lai, Catherine L.; Vitagliano, Tennille L.; Rouet, Romain; Christ, Daniel; Tang, Benjamin; West, Nicholas P.; George, Shane; Gerrard, John; Croucher, Peter I.; Kelleher, Anthony D.; Goodnow, Christopher G.; Sprent, Jonathan D.; Powell, Joseph D.; Brilot, Fabienne; Nanan, Ralph; Hsu, Peter S.; Deenick, Elissa K.; Britton, Philip N.; Phan, Tri GiangPublished 2022SUMMARY Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the ...Preprint -
Immunizations with diverse sarbecovirus receptor binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
Burnett, Deborah L; Jackson, Katherine J L; Langley, David B; Aggrawal, Anupria; Stella, Alberto Ospina; Johansen, Matt D; Balachandran, Harikrishnan; Lenthall, Helen; Rouet, Romain; Walker, Gregory; Saunders, Bernadette M; Singh, Mandeep; Li, Hui; Henry, Jake Y; Jackson, Jennifer; Stewart, Alastair G; Witthauer, Franka; Spence, Matthew A; Hansbro, Nicole G; Jackson, Colin; Schofield, Peter; Milthorpe, Claire; Martinello, Marianne; Schulz, Sebastian R; Roth, Edith; Kelleher, Anthony; Emery, Sean; Britton, Warwick J; Rawlinson, William D; Karl, Rudolfo; Schäfer, Simon; Winkler, Thomas H; Brink, Robert; Bull, Rowena A; Hansbro, Philip M; Jäck, Hans-Martin; Turville, Stuart; Christ, Daniel; Goodnow, Christopher CPublished 2021Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies against sites that are evolutionarily conserved across the ...Article -
Long-term persistence of neutralizing memory B cells in SARS-CoV-2
Bull, Rowena; Abayasingam, Arunasingam; Balachandran, Harikrishnan; Agapiou, David; Rodrigo, Chaturaka; Keoshkerian, Elizabeth; Li, Hui; Brasher, Nicholas; Christ, Daniel; Rouet, Romain; Burnett, Deborah; Grubor-Bauk, Branka; Rawlinson, William; Turville, Stuart; Aggarwal, Anupriya; Brilot, Fabienne; Mina, Michael; Post, Jeffrey; Hudson, Bernard; Gilroy, Nicky; Dwyer, Dominic; Sasson, Sarah; Tea, Fiona; Pilli, Deepti; Tedla, Nicodemus; Lloyd, Andrew; Martinello, MariannePublished 2020Considerable concerns relating to the duration of protective immunity against SARS-CoV-2 have been raised, with evidence of antibody titres declining rapidly after infection and reports of reinfection. Here we monitored ...Preprint -
Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses
Balachandran, Harikrishnan; Phetsouphanh, Chansavath; Agapiou, David; Adhikari, Anurag; Rodrigo, Chaturaka; Hammoud, Mohamed; Shrestha, Lok Bahadur; Keoshkerian, Elizabeth; Gupta, Money; Turville, Stuart; Christ, Daniel; King, Cecile; Sasson, Sarah; Bartlett, Adam; Grubor-Bauk, Branka; Rawlinson, William; Aggarwal, Anupriya; Stella, Alberto Ospina; Klemm, Vera; Mina, Michael M.; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Konecny, Pam; Ahlenstiel, Golo; Dwyer, Dominic; Sorrell, Tania C.; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena AnnePublished 2021Understanding the long-term maintenance of SARS-CoV-2 immunity is critical for prediction of protection against reinfection. In a cohort of 24 participants, the association of disease severity and early immunological ...Preprint -
Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses
Balachandran, Harikrishnan; Phetsouphanh, Chansavath; Agapiou, David; Adhikari, Anurag; Rodrigo, Chaturaka; Hammoud, Mohamed; Shrestha, Lok Bahadur; Keoshkerian, Elizabeth; Gupta, Money; Turville, Stuart; Christ, Daniel; King, Cecile; Sasson, Sarah C.; Bartlett, Adam; Grubor-Bauk, Branka; Rawlinson, William; Aggarwal, Anupriya; Stella, Alberto Ospina; Klemm, Vera; Mina, Michael M.; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Konecny, Pam; Ahlenstiel, Golo; Dwyer, Dominic E.; Sorrell, Tania C.; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena A.; Group, COSIN StudyPublished 2022Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 ...Article
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