Browsing by author "Bradbury, Peta"
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Occupy tissue: the movement in cancer metastasis
Bradbury, Peta; Fabry, Ben; O’Neill, Geraldine M.Published 2012-09-01The critical role of migration and invasion in cancer metastasis warrants new therapeutic approaches targeting the machinery regulating cell migration and invasion. While 2-dimensional (2D) models have helped identify a ...Open AccessArticle -
PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9
Bradbury, Peta; Mahmassani, Maha; Zhong, Jessie; Turner, Kylie; Paul, Andre; Verrills, Nicole M.; O'Neill, Geraldine M.Published 2012-02-01The mesenchymal mode of cancer cell invasion characterized by active adhesion turnover and a polarized actin cytoskeleton, is critically regulated by the adaptor protein NEDD9/HEF1/Cas-L. While it is known that NEDD9 is ...Open AccessArticle -
Src Kinase Determines the Dynamic Exchange of the Docking Protein NEDD9 (Neural Precursor Cell Expressed Developmentally Down-regulated Gene 9) at Focal Adhesions
Bradbury, Peta; Bach, Cuc T.; Paul, Andre; O’Neil, Geraldine M.Published 2014-09-05Dynamic exchange of molecules between the cytoplasm and integrin-based focal adhesions provides a rapid response system for modulating cell adhesion. Increased residency time of molecules that regulate adhesion turnover ...Open AccessArticle -
Structural homology and functional similarity: Cas family proteins, NEDD9 and p130Cas are functionally distinct focal adhesion molecules
Bradbury, PetaPublished 2016-03-30The majority of work to date pertaining to the Cas family proteins has focused on specifically on p130Cas. Thus, given the strong sequence and structural homologies shared between NEDD9 and p130Cas, similar roles have been ...USyd AccessThesis -
Tyrosine Y189 in the Substrate Domain of the Adhesion Docking Protein NEDD9 Is Conserved with p130Cas Y253 and Regulates NEDD9-Mediated Migration and Focal Adhesion Dynamics
Baquiran, Jaime B.; Bradbury, Peta; O’Neill, Geraldine M.Published 2013-07-09The focal adhesion docking protein NEDD9/HEF1/Cas-L regulates cell migration and cancer invasion. NEDD9 is a member of the Cas family of proteins that share conserved overall protein-protein interaction domain structure, ...Open AccessArticle
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