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|Title: ||An evaluation of Psychotropic medicines use: Patterns and outcomes|
|Authors: ||GISEV, Natasa|
|Issue Date: ||9-Jan-2014|
|Publisher: ||University of Sydney, Pharmacy|
|Abstract: ||Psychotropic medicines play an integral role in the management of many mental disorders. However, their quality, or rational use, is central to achieving optimal outcomes. This thesis evaluates the patterns and outcomes associated with psychotropic medicines use in the community, focusing on two distinct study populations which are challenging to manage in clinical practice: (1) individuals receiving compulsory treatment through a community treatment order (CTO) in New South Wales, Australia, and (2) community-dwelling older adults aged 65 years and older residing in Leppävirta, Finland. Using these two populations, a number of controversial aspects of psychotropic medicines use were examined retrospectively using different approaches and data sources. For the study undertaken among individuals issued a CTO, case notes and treatment plans were sourced to evaluate use of long-acting injectable antipsychotics, antipsychotic polypharmacy and high-dose antipsychotics. Additionally, the factors associated with antipsychotic polypharmcy and high-dose antipsychotics were identified, and the rates of persistence with these prescribing practices were determined. For the study undertaken among older adult residents of Leppävirta, linked administrative datasets were used to establish the risk of death associated with use of antipsychotics and benzodiazepines. The findings and implications of each of these studies are discussed in detail.|
|Access Level: ||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions: ||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
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|GISEV Natasa - Final thesis.pdf||3.19 MB||Adobe PDF|
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