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|Title: ||THE INFLUENCE OF FORMULATION VARIABLES ON PARTICLES GENERATED FROM SOLUTION BASED PRESSURIZED METERED DOSE INHALERS|
|Authors: ||Zhu, Bing|
|Keywords: ||pressurized metered dose inhalers, aerosol performance, particle formation, physico-chemical properties, co-solvent, non-volatile components|
|Issue Date: ||21-Nov-2013|
|Publisher: ||University of Sydney. Pharmacology, School of Medical Sciences|
|Abstract: ||The main aims of this work were to investigate the aerosol performance, particle formation process and physico-chemical properties of particles produced from solution-based pressurized metered dose inhalers (pMDIs) formulated with different co-solvent concentrations. In addition, the influences of different active pharmaceutical compounds and glycerol as the non-volatile components were also evaluated.
This thesis demonstrated the complex nature of particle formation in solution based pMDIs and investigated the influence of co-solvent (e.g. ethanol) and non-volatile additives (e.g. glycerol and drug type) on aerosol performance, particle maturation, morphology and the physico-chemical properties of the final ‘deposited’ drug system. Significant differences in all the above factors were observed when these variables were altered and the properties could be related to the mechanisms of aerosol generation and the nature of the additives. Ultimately, this enhanced the knowledge in the field that may be used when developing new solution based pMDI systems.|
|Access Level: ||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions: ||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
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|ZHU Bing - Final Thesis.pdf||46.5 MB||Adobe PDF|
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