Allison, SJ; Baldock, PA; Sainsbury, Amanda; Enriquez, R; Lee, NJ; Lin, EJD; Klugmann, M; During, M; Eisman, JA; Li, M; Pan, LC; Herzog, H
Reduction in levels of sex hormones at menopause in women is associated with two common, major outcomes, the accumula- tion of white adipose tissue, and the progressive loss of bone because of excess osteoclastic bone ...
The importance of neuropeptide Y (NPY) and Y2 receptors in the regulation of bone and energy homeostasis has recently been demonstrated. However, the contributions of the other Y recep- tors are less clear. Here we show ...
Sainsbury, Amanda; Baldock, PA; Schwarzer, CJ; Ueno, N; Enriquez, RF; Couzens, M; Inui, A; Herzog, H; Gardiner, EM
Neuropeptide Y regulates numerous physiological processes via at least five different Y receptors, but the specific roles of each receptor are still unclear. We previously demonstrated that Y2 receptor knockout results in ...
Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central ...
Germ line or hypothalamus-specific deletion of Y2 receptors in mice results in a doubling of trabecular bone volume. However, the specific mechanism by which deletion of Y2 receptors increases bone mass has not yet been ...
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