Messier, Stephen P; Mihalko, Shannon L; Beavers, Daniel P; Nicklas, Barbara J.; DeVita, Paul; Carr, J. Jeffery; Hunter, David J.; Williamson, Jeff D; Bennell, Kim L; Guermazi, Ali; Lyles, Mary; Loeser, Richard F.
Background Muscle loss and fat gain contribute to the disability, pain, and morbidity associated with knee osteoarthritis (OA), and thigh muscle weakness is an independent and modifiable risk factor for it. However, while ...
Kraus, Virginia Byers; Feng, Sheng; Wang, Sheng Chu; White, Scott; Ainslie, Maureen; Le Graverand, Marie-Pierre Hellio; Brett, Alan; Eckstein, Felix; Hunter, David J.; Lane, Nancy E; Taljanovic, Mihra S.; Schnitzer, Thomas; Charles, H Cecil
OBJECTIVE: To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression. METHODS: Longitudinal (baseline, 12-month, and 24-month) knee radiographs were ...
Suri, Pradeep; Hunter, David J.; Rainville, James; Guermazi, Ali; Katz, Jeffrey N.
Objective To determine whether the presence and extent of severe lumbar facet joint osteoarthritis (OA) are associated with back pain in older adults, accounting for disc height narrowing and other covariates. Design ...
Losina, Elena; Weinstein, Alexander M.; Reichmann, William M.; Burbine, Sara A.; Solomon, Daniel H.; Daigle, Meghan E.; Rome, Benjamin N.; Chen, Stephanie P.; Hunter, David J.; Suter, Lisa G.; Jordan, Joanne M.; Katz, Jeffrey N.
OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. METHODS: We estimated the incidence ...
Osteoarthritis (OA) is the leading cause of disability among older adults. It is an incredibly prevalent condition affecting upward of 1 in 8 adults. Societal trends in aging, obesity, and increasing joint injury will lead ...
Eyles, Jillian; Lucas, Barbara R; Hunter, David J.
International evidence-based guidelines recommend a multitude of nonsurgical treatment options for the management of osteoarthritis. This article summarizes the evidence available for patient characteristics that have been ...
Messier, Stephen P; Mihalko, Shannon L; Legault, Claudine; Miller, Gary D.; Nicklas, Barbara J.; DeVita, Paul; Beavers, Daniel P; Hunter, David J.; Lyles, Mary F.; Eckstein, Felix; Williamson, Jeff D; Carr, J. Jeffery; Guermazi, Ali; Loeser, Richard F.
Importance Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective To determine whether a ≥10% reduction in body weight ...
Riordan, Edward A; Frobell, Richard B; Roemer, Frank W.; Hunter, David J.
Although there is an abundance of literature regarding the development of knee osteoarthritis after rupture of the anterior cruciate ligament (ACL), the mechanism underlying this link is not clear. Recent studies have ...
van der Esch, Martin; Knoop, Jesper; Hunter, David J.; Klein, Jan-Paul; van der Leeden, Marike; Knol, Dirk L; Reiding, Dick; Vooreman, Ramon E; Gerritsen, Martijn; Roorda, Leo D; Lems, Willem F; Dekker, Joost
BACKGROUND: Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of ...
Williams, Frances M K; Bansal, Aruna T; van Meurs, Joyce B; Bell, Jordana T; Meulenbelt, Ingrid; Suri, Pradeep; Rivadeneira, Fernando; Sambrook, Philip N; Hofman, Albert; Bierm-Zeinstra, Sita; Menni, Cristina; Kloppenburg, Megreet; Slagboom, P Eline; Hunter, David J.; MacGregor, Alex J; Uitterlinden, Andre G.; Spector, Tim D
OBJECTIVE: Lumbar disc degeneration (LDD) is an important cause of low back pain, which is a common and costly problem. LDD is characterised by disc space narrowing and osteophyte growth at the circumference of the disc. ...
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