Now showing items 21-40 of 43

    • Management of osteoarthritis of the knee 

      Bennell, Kim L; Hunter, David J.; Hinman, Rana S (British Medical Journal, 2012-07-30)
      Osteoarthritis is a chronic disease; management should be patient centred and coordinated, with attention to modifiable risk factors and comorbidities Focus on conservative non-drug treatment, particularly exercise; for ...
    • Long term joint consequences of sporting activity: preventing and managing osteoarthritis in the athlete 

      Bennell, Kim L; Hunter, David J.; Vicenzino, Bill (Nature Publishing Group, 2012-07-31)
      Sports participation is associated with an increased risk of future osteoarthritis (OA), much of which results from joint injury. No strong evidence exists that moderate sporting activity in the presence of normal joints ...
    • Purine-Rich Foods Intake and Recurrent Gout Attacks 

      Zhang, Yuqing; Chen, Clara; Choi, Hyon; Chaisson, Christine E; Hunter, David J.; Niu, Jingbo; Neogi, Tuhina (BMJ, 2012-09)
      OBJECTIVE: To examine and quantify the relation between purine intake and the risk of recurrent gout attacks among gout patients. METHODS: The authors conducted a case-crossover study to examine associations of a set ...
    • Osteoarthritis: What does imaging tell us about its etiology. 

      Johnson, Victoria L; Giuffre, Bruno M; Hunter, David J. (Thieme Medical Publishers, 2012-11)
      Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. Due to an aging population and increasing obesity, the incidence of OA is rising. The etiology of OA is multifactorial and complex; ...
    • The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features 

      Katz, Jeffrey N.; Chaisson, Christine E; Cole, Brian; Guermazi, Ali; Hunter, David J.; Jones, Morgan; Levy, Bruce A; Mandi, Lisa A; Martin, Scott; Marx, Robert G; Safran-Norton, Clare; Roemer, Frank W.; Skoniecki, Debra; Solomon, Daniel H.; Spindler, Kurt P.; Wright, John; Wright, Rick W; Losina, Elena (Elsevier, 2012-11)
      This paper presents the rationale and design features of the MeTeOR Trial (Meniscal Tear in Osteoarthritis Research; Clinical Trials.gov NCT00597012). MeTeOR is an NIH-funded seven-center prospective randomized controlled ...
    • THE RELATIONSHIP OF TIBIAL BONE PERFUSION TO PAIN IN KNEE OSTEOARTHRITIS. 

      Seah, S; Wheaton, D; Li, Ling; Dyke, J P; Talmo, C; Harvey, William F; Hunter, David J. (Elsevier, 2012-12)
      Objective To confirm altered perfusion within tibial bone marrow lesions (BMLs) and improve our understanding on the relationship between BMLs and pain in knee osteoarthritis (OA). Methods Participants with moderate ...
    • EFFECTS OF INTENSIVE DIET AND EXERCISE ON KNEE JOINT LOADS, INFLAMMATION, AND CLINICAL OUTCOMES AMONG OVERWEIGHT AND OBESE ADULTS WITH KNEE OSTEOARTHRITIS 

      Messier, Stephen P; Mihalko, Shannon L; Legault, Claudine; Miller, Gary D.; Nicklas, Barbara J.; DeVita, Paul; Beavers, Daniel P; Hunter, David J.; Lyles, Mary F.; Eckstein, Felix; Williamson, Jeff D; Carr, J. Jeffery; Guermazi, Ali; Loeser, Richard F. (The Journal of the American Medical Association, 2013)
      Importance Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective To determine whether a ≥10% reduction in body ...
    • Strength Training for Arthritis Trial (START): design and rationale 

      Messier, Stephen P; Mihalko, Shannon L; Beavers, Daniel P; Nicklas, Barbara J.; DeVita, Paul; Carr, J. Jeffery; Hunter, David J.; Williamson, Jeff D; Bennell, Kim L; Guermazi, Ali; Lyles, Mary; Loeser, Richard F. (BMC Musculoskeletal Disorders, 2013)
      Background Muscle loss and fat gain contribute to the disability, pain, and morbidity associated with knee osteoarthritis (OA), and thigh muscle weakness is an independent and modifiable risk factor for it. However, ...
    • The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament 

      Riordan, Edward A; Frobell, Richard B; Roemer, Frank W.; Hunter, David J. (Elsevier, 2013-02)
      Although there is an abundance of literature regarding the development of knee osteoarthritis after rupture of the anterior cruciate ligament (ACL), the mechanism underlying this link is not clear. Recent studies have ...
    • Imaging of Osteoarthritis 

      Guermazi, Ali; Hayashi, Daichi; Eckstein, Felix; Hunter, David J.; Duryea, Jeff; Roemer, Frank W. (Elsevier, 2013-02)
      Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment. Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral ...
    • Osteoarthritis Preface 

      Hunter, David J. (Elsevier, 2013-02)
      Osteoarthritis (OA) is the leading cause of disability among older adults. It is an incredibly prevalent condition affecting upward of 1 in 8 adults. Societal trends in aging, obesity, and increasing joint injury will lead ...
    • 'Targeting care: tailoring non-surgical management according to clinical presentation' 

      Eyles, Jillian; Lucas, Barbara R; Hunter, David J. (Rheumatic diseases clinics of North America, 2013-02)
      International evidence-based guidelines recommend a multitude of nonsurgical treatment options for the management of osteoarthritis. This article summarizes the evidence available for patient characteristics that have been ...
    • Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing - data from the Osteoarthritis Initiative. 

      Bloecker, K; Guermazi, Ali; Wirth, W; Benichou, O; Kwoh, C. Kent; Englund, M; Hunter, David J.; Resch, H; Eckstein, Felix (Elsevier, 2013-03)
      INTRODUCTION: Meniscal extrusion is thought to be associated with less meniscus coverage of the tibial surface, but the association of radiographic disease stage with quantitative measures of tibial plateau coverage is ...
    • Quantitative MRI measures of cartilage predict knee replacement: a case-control study from the Osteoarthritis Initiative. 

      Eckstein, Felix; Kwoh, C. Kent; Boudreau, Robert M; Wang, Zhiiie; Hannon, Michael J; Cotofana, Sebastian; Hudelmaier, Martin I; Wirth, Wolfgang; Guermazi, Ali; Nevitt, Michael; John, Markus R.; Hunter, David J. (BMJ, 2013-05)
      OBJECTIVE: Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular ...
    • Disease-modifying drugs for knee osteoarthritis: can they be cost-effective? 

      Losina, Elena; Daigle, Meghan E.; Reichmann, William M.; Suter, Lisa G.; Hunter, David J.; Solomon, Daniel H.; Walensky, Rochelle P.; Jordan, Joanne M.; Burbine, Sara A.; Patiel, A. Daniel; Katz, Jeffrey N. (Elsevier, 2013-05)
      OBJECTIVE: Disease-modifying osteoarthritis drugs (DMOADs) are under development. Our goal was to determine efficacy, toxicity, and cost thresholds under which DMOADs would be a cost-effective knee OA treatment. DESIGN: ...
    • Lifetime risk and age of diagnosis of symptomatic knee osteoarthritis in the US 

      Losina, Elena; Weinstein, Alexander M.; Reichmann, William M.; Burbine, Sara A.; Solomon, Daniel H.; Daigle, Meghan E.; Rome, Benjamin N.; Chen, Stephanie P.; Hunter, David J.; Suter, Lisa G.; Jordan, Joanne M.; Katz, Jeffrey N. (Willey, 2013-05)
      OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population. METHODS: We estimated the incidence ...
    • The association between reduced knee joint proprioception and medial meniscal abnormalities using MRI in knee osteoarthritis: results from the Amsterdam osteoarthritis cohort. 

      van der Esch, Martin; Knoop, Jesper; Hunter, David J.; Klein, Jan-Paul; van der Leeden, Marike; Knol, Dirk L; Reiding, Dick; Vooreman, Ramon E; Gerritsen, Martijn; Roorda, Leo D; Lems, Willem F; Dekker, Joost (Elsevier, 2013-05)
      BACKGROUND: Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of ...
    • Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea 

      Kim, I. J.; Kim, D. H.; Jung, J. Y.; Song, Y. W.; Guermazi, Ali; Crema, M. D.; Hunter, David J.; Kim, H. A. (Osteoarthritis and Cartilage, 2013-05-01)
      Objective: To describe the frequency of bonemarrowlesions (BMLs) detected bymagnetic resonance imaging (MRI), and to examine the association of BMLs with knee pain severity in community residents in Korea. Methods: ...
    • Structural correlates of pain in joints with osteoarthritis. 

      Hunter, David J.; Guermazi, Ali; Roemer, Frank; Zhang, Yuqing; Neogi, Tuhina (Elsevier, 2013-05-23)
      Objective: To describe the insights on the epidemiology of pain-structure association and the ramifications of these studies for clinical trials. Design: Narrative review summarizing the pertinent literature in this area, ...
    • Subchondral Bone Trabecular Integrity Predicts and Changes Concurrently with Radiographic and MRI Determined Knee Osteoarthritis Progression 

      Kraus, Virginia Byers; Feng, Sheng; Wang, Sheng Chu; White, Scott; Ainslie, Maureen; Le Graverand, Marie-Pierre Hellio; Brett, Alan; Eckstein, Felix; Hunter, David J.; Lane, Nancy E; Taljanovic, Mihra S.; Schnitzer, Thomas; Charles, H Cecil (John Wiley & Sons, 2013-07)
      OBJECTIVE: To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression. METHODS: Longitudinal (baseline, 12-month, and 24-month) knee radiographs were ...