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dc.contributor.authorIkhimwin, Bernard Osayimwense
dc.date.accessioned2020-07-16
dc.date.available2020-07-16
dc.date.submitted2020-01-01en_AU
dc.identifier.urihttps://hdl.handle.net/2123/22892
dc.description.abstractThis thesis describes a computational model for an initial/pre-collecting lymphatic network and a study on valvogenesis (formation of valves in the lymphatics during embryonic development). The computational model was applied to rat mesenteric lymphatic networks (19- and 163-segment) with sparse secondary valves. The network was simulated with these secondary valves being operational and non-operational. Sensitivity of parameters like the vessel stiffness, interstitial resistance, and the availability of primary valves, on the cycle-mean outflow-rate from the 19-segment network was considered. Results for the study on valvogenesis, simulations done on the 2D images of embryonic skin lymphatic network suggest that fluid shear stress does not localize the expression of Prox1 (a transcription factor responsible for valve formation).en_AU
dc.language.isoenen_AU
dc.publisherUniversity of Sydneyen_AU
dc.subjectlymphaticsen_AU
dc.subjectvalvogenesisen_AU
dc.subjectfluid-flowen_AU
dc.titleA computational model of the initial/pre-collecting lymphatics, and a study of lymphatic valvogenesisen_AU
dc.typeThesis
dc.type.thesisDoctor of Philosophyen_AU
dc.rights.otherThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
usyd.facultySeS faculties schools::Faculty of Science::School of Mathematics and Statisticsen_AU
usyd.degreeDoctor of Philosophy Ph.D.en_AU
usyd.awardinginstThe University of Sydneyen_AU
usyd.advisorMyerscough, Mary


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