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dc.contributor.authorWijaya, Ratna Sari
dc.date.accessioned2020-02-14T03:45:19Z
dc.date.available2020-02-14T03:45:19Z
dc.date.submitted2019-06
dc.identifier.urihttps://hdl.handle.net/2123/21846
dc.description.abstractNatural killer (NK) cells play an important role in the host defence against pathogens and cancer. NK cell function is tightly regulated by signals from activating and inhibitory receptors. The receptor repertoire of NK cells is shaped by maturation and the exposure to various environmental factors including viral infection, resulting in a remarkable degree of NK cell diversity. Further, recent data from studies in mice suggests that NK cells can acquire a memory phenotype, however, human data is sparse. This thesis describes the NK cells changes that result from chronic hepatitis B virus (HBV) infection. This includes (1) the identification of a novel KLRG1+ NK cell subset with antifibrotic capabilities, (2) first in human description of memory NK cells sharing the cardinal features of immune memory such as antigen specificity and longevity, and (3) the evolution of an inhibited dysfunctional CD56neg NK cells subset including in-depth functional studies. Overall, this thesis identified the novel roles of human NK cells, specifically in the context of hepatitis B infection. These findings, particularly those relating to anti-fibrotic NK cells and memory NK cells provide novel cellular targets to stop liver fibrosis progression and potentially eradicate hepatitis B. Further, such concepts could be translated to other chronic infections or cancer.en_AU
dc.publisherUniversity of Sydneyen_AU
dc.publisherFaculty of Medicine and Healthen_AU
dc.publisherWestmead Clinical Schoolen_AU
dc.rightsThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
dc.subjectNKen_AU
dc.subjecthepatitis B virusen_AU
dc.subjectCD56en_AU
dc.titleAdaptive immune features and characteristics of natural killer cells in hepatitis B infectionen_AU
dc.typePhD Doctorateen_AU
dc.type.pubtypeDoctor of Philosophy Ph.D.en_AU
dc.description.disclaimerAccess is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.en_AU


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