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dc.contributor.authorGouveia, Bruna Melhoranse
dc.date.accessioned2019-10-02
dc.date.available2019-10-02
dc.date.issued2019-05-16
dc.identifier.urihttp://hdl.handle.net/2123/21176
dc.description.abstractBackground: Over the last few decades, Reflectance Confocal Microscopy (RCM) has been tested as a diagnostic technique and recently, demonstrates effectiveness to monitor the therapeutic response in melanoma and non-melanoma skin cancer, but it has not been used for follow-up in Cutaneous Lymphoma. This innovative technology allows an in vivo dynamic evaluation of multiple lesions and helps to identify areas of active disease. Moreover, the non-invasive nature of this technique allows repetitive sampling without biopsy collection, causing no further morbidity to patients. Its main advantage is the possibility of risk-free longitudinal monitoring. Objective: Our aim was to evaluate the role of RCM in the follow-up of patients with Mycosis Fungoides (MF). Additionally, to correlate RCM features with clinical and histopathological features before and after treatment. Method: Patients were assessed with RCM on the same site that diagnostic biopsies were performed and re-assessed 6 months after treatment. RCM descriptors were defined by a systematic review. Histopathological correlation and clinical correlation were assessed. Results: A total of 30 patients were assessed by RCM and biopsies were taken in 38 lesions. After 20 to 30 weeks under treatment, 19 lesions were re-assessed by RCM and 12 were re-biopsied. RCM demonstrated good correlation with clinical and histopathological assessments with 4 RCM parameters (epidermotropic lymphocytes, Pautier’s microabscess, interface dermatitis and junctional lymphocytes) achieving an AUC 0.955 (SD: 0.053, p: 0.003). Conclusion: RCM is an excellent tool to assess the response of skin lesion in patients with MF, with excellent correlation with clinic and histological assessment. Keywords: Follow up, Score, Cutaneous T-cell lymphoma, Skin cancer, Reflectance Confocal Microscopy, Mycosis Fungoidesen_AU
dc.rightsThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
dc.subjectreflectance confocal microscopyen_AU
dc.subjectmycosis fungoidesen_AU
dc.subjectT-cell Lymphomaen_AU
dc.subjectfollow upen_AU
dc.subjectconfocal scoreen_AU
dc.subjectskin canceren_AU
dc.titleThe Role of in vivo Reflectance Confocal Microscopy in Cutaneous T-cell Lymphoma follow upen_AU
dc.typeThesisen_AU
dc.type.thesisDoctor of Philosophyen_AU
usyd.facultyFaculty of Medicine and Healthen_AU
usyd.degreeDoctor of Philosophy Ph.D.en_AU
usyd.awardinginstThe University of Sydneyen_AU


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