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dc.contributor.authorLesmana, Brian
dc.date.accessioned2019-09-13
dc.date.available2019-09-13
dc.date.issued2019-06-28
dc.identifier.urihttp://hdl.handle.net/2123/21115
dc.description.abstractBackground/Objective: Androgens are not currently part of the therapeutic guidelines in burns management. However, oxandrolone, an androgen analogue, has been reported to have significant benefits in burn wound recovery, but there are still concerns regarding its side effect profile. Preliminary studies have identified that the inactivation of androgen receptors (AR) slows wound healing post-burn injury. This finding is opposite to that of experimental evidence for androgens in cutaneous (non-burn) wound healing, on which they exert an inhibitory effect. Therefore, this study aimed to identify the role of androgen signalling in severe, hypermetabolic burn injury both at the local wound and systemic levels. Design: Experimental study. Setting: Research laboratory. Subjects: Male Balb/c mice; wild type (WT) and androgen receptor knockout (ARKO) using Cre/LoxP system. Interventions: 4 cm2 contact burn injury (representing 10% Total Body Surface Area (TBSA)). Main Results: ARKO mice demonstrated slower wound healing and poorer body weight maintenance and recovery. This was associated with preferential activation of white adipose tissue over brown adipose tissue, larger splenic size and smaller hepatic size. There was no difference in local wound inflammatory cytokine mRNA expression between WT and ARKO mice. Conclusions: Androgens play a positive modifying role in wound healing in the context of burn injury, a finding opposite to its reported inhibitory actions in cutaneous wound healing. This is likely resultant from an attenuation of the systemic hypermetabolic response. This contradictory, contextdependent action urges further research into the beneficiary effects of androgens in burns management, particularly its modulation of systemic inflammation and the host immune response.en_AU
dc.rightsThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
dc.subjectandrogensen_AU
dc.subjectburnsen_AU
dc.subjectwound healingen_AU
dc.subjectburn injuryen_AU
dc.titleThe Role of Androgens in Burn Wound Healingen_AU
dc.typeThesisen_AU
dc.type.thesisMasters by Researchen_AU
usyd.facultyFaculty of Medicine and Health, Concord Clinical Schoolen_AU
usyd.degreeMaster of Philosophy M.Philen_AU
usyd.awardinginstThe University of Sydneyen_AU


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