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dc.contributor.authorOveissi, Farshad
dc.date.accessioned2019-05-10
dc.date.available2019-05-10
dc.date.issued2019-05-10
dc.identifier.urihttp://hdl.handle.net/2123/20399
dc.description.abstractTough hydrogels with mechanical properties that resemble human soft tissues are promising for applications in biomedical, soft robotics, and biocompatible electronics. However, their synthesis and production may require multi-step processing, their mechanical properties could not be tuned or adjusted for a desirable application, and they may not be biocompatible. This thesis aimed to address these shortfalls by designing a versatile hydrogel system with tuneable properties and a facile one-pot fabrication process. Hydrophilic polyurethane (HPU) was chosen as the physically-crosslinked network, due to its robustness, superior elasticity, and rapid load recovery. Two different strategies were undertaken to develop tough, functional and biocompatible hydrogels from (HPU). In the first strategy, lignin was used as a crosslinker. The addition of lignin enhanced the mechanical properties, broadened the processability of HPU, and enabled 3D printing and fibre spinning of this polymer. In the second strategy, a library of semi-interpenetrating hydrogels comprised of an HPU network and a copolymer crosslinked with long chain crosslinkers that was functionalised with succinimide groups were developed. The addition of succinimide groups allowed the conjugation of proteins to this class of hydrogels to promote biocompatibility. This topology enhanced the degrees of freedom for manipulation of mechanical and physical properties of HPU hydrogel by adjusting the ratio of physically-crosslinked to chemically-crosslinked networks and the composition of the building components in the chemically-crosslinked network. One-pot synthesis, ease of processability and their mechanical properties similar to human soft tissues along with biocompatibility, made this library of hydrogels superior to the existing hydrogels and made them potential candidates for the fabrication of medical devices and soft robotics.en_AU
dc.rightsThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
dc.titleTough Hydrogels with Tuneable Physicomechanical Characteristics for Medical Devicesen_AU
dc.typeThesisen_AU
dc.type.thesisDoctor of Philosophyen_AU
usyd.facultyFaculty of Engineering and Information Technologies, School of Chemical and Biomolecular Engineeringen_AU
usyd.degreeDoctor of Philosophy Ph.D.en_AU
usyd.awardinginstThe University of Sydneyen_AU


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