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dc.contributor.authorDeeba, Farah
dc.date.accessioned2019-04-29
dc.date.available2019-04-29
dc.date.issued2018-09-21
dc.identifier.urihttp://hdl.handle.net/2123/20331
dc.description.abstractA quantitative analysis of the dynamics of generalized epileptic seizures is carried out by using a neural field model of the corticothalamic system in the presence of a temporally varying connection strength between the cerebral cortex and thalamus. The temporal and dynamical characteristics of generalized absence seizure and tonic-clonic seizures and the interictal oscillations in between two successive seizures are analyzed and related to the corresponding physiological changes of the connection strength. It is found that the spectral, temporal, and physiological characteristics of seizure oscillations changes with the rate of change and amplitude of the connection strength, including appearance of a saddle-cycle at high ramp rates in the tonic-clonic case. The transitions between different states during seizures are inversely proportional to the square root of the ramp rate. The amplitude and sharpness of the interictal oscillations increase with the maximum connection strength, and the number of oscillations only depends on the duration above the threshold.en_AU
dc.rightsThe author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.en_AU
dc.subjectBrain Dynamicsen_AU
dc.subjectEpilepsyen_AU
dc.subjectSeizureen_AU
dc.subjectNeural Field Theoryen_AU
dc.subjectInterictal Eventsen_AU
dc.subjectNFTSimen_AU
dc.titleQuantitative modeling of epileptic seizures and interictal eventsen_AU
dc.typeThesisen_AU
dc.type.thesisDoctor of Philosophyen_AU
usyd.facultyFaculty of Science, School of Physicsen_AU
usyd.degreeDoctor of Philosophy Ph.D.en_AU
usyd.awardinginstThe University of Sydneyen_AU


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