Please use this identifier to cite or link to this item:
Full metadata record
|dc.description.abstract||The thesis is comprised of a series of studies that characterise the potential of inhaled therapy for treatment of TB using rifapentine as a model. Novel inhalable dry powder formulations containing efflux pump inhibitors (verapamil or thioridazine) and rifapentine were successfully formulated. These powders demonstrated excellent aerosol performance and enhanced in vitro activity against intracellular growth of M. tuberculosis compared to single drug treatments. Alternatively, rifapentine-PLGA particles regardless of monomer and molecular weight showed good aerosol performance and higher affinity for macrophage uptake. In the following study, a modified Aerolizer® as a low-cost generic device demonstrated promising results for delivery of rifapentine up to a maximum dose of 100 mg in a single capsule. Finally, it was found that intratracheal delivery of rifapentine (20 mg/kg) triggered a transient neutrophil influx in the lungs which resolved by 7 days post-dosing. These findings suggest that the inhaled rifapentine is more suitable for periodic dosing (i.e. weekly) and as an adjunct to the standard oral anti-TB drug regimen.||en_AU|
|dc.publisher||University of Sydney||en_AU|
|dc.publisher||Faculty of Pharmacy||en_AU|
|dc.subject||pulmonary drug delivery||en_AU|
|dc.title||Inhaled anti-tubercular therapy: Dry powder formulations, device and toxicity challenges||en_AU|
|dc.type.pubtype||Doctor of Philosophy Ph.D.||en_AU|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
This work is protected by Copyright. All rights reserved. Access to this work is provided for the purposes of personal research and study. Except where permitted under the Copyright Act 1968, this work must not be copied or communicated to others without the express permission of the copyright owner. Use the persistent URI in this record to enable others to access this work.
|Parumasivam_TP_thesis.pdf||Thesis||8.5 MB||Adobe PDF|
Items in Sydney eScholarship Repository are protected by copyright, with all rights reserved, unless otherwise indicated.