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|Title: ||Enhancing the Power of Endogenous Protein Phosphatase 2A to Combat Asthmatic Inflammation: Role for MAPKs and Tristetraprolin|
|Authors: ||Rahman, Md. Mostafizur|
|Issue Date: ||4-Jan-2016|
|Publisher: ||University of Sydney|
Faculty of Pharmacy
|Abstract: ||Asthma is a chronic inflammatory disease, and thus corticosteroids are the mainstay of anti-inflammatory therapy to combat the disease. Typically asthma management involves long term use of corticosteroids, which often leads to severe side effects. Although corticosteroids have proven clinical efficacy in asthma, many asthmatic inflammatory conditions (e.g. infection, exacerbation) are not responsive to them. Therefore, alternative anti-inflammatory strategies are urgently needed and enhancing the function of endogenous PP2A, offer great promise. PP2A is a master controller of multiple inflammatory signalling pathways driven by MAPKs and is a target in asthma. Therefore in this thesis I aim to explore the role of PP2A in the context of asthmatic inflammation.
Studies performed in this thesis provide a greater understanding of the role of some widely used inflammatory mediators such as TNFα, S1P and Pam3CSK and most importantly, the anti-inflammatory impact of PP2A. Our studies partly revealed the underlying molecular mechanisms of endogenous PP2A and its relationship with the critical anti-inflammatory protein, TTP. Besides, these studies clearly demonstrate that PP2A activators can enhance the anti-inflammatory function of TTP and repress inflammation when corticosteroid insensitivity exists. Therefore we presume that PP2A activators may have implications as alternative anti-inflammatory strategies to combat asthmatic inflammation.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
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|RAHMAN Md. Mostafizur - Final Thesis.pdf||Thesis||3.18 MB||Adobe PDF|
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