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|Title: ||Defining The Role Of The Major Subsets Of Renal Mononuclear Phagocytes For Potential Therapies|
|Authors: ||CAO, QI|
|Issue Date: ||25-Nov-2015|
|Publisher: ||University of Sydney|
Sydney Medical School
|Abstract: ||Chronic kidney disease (CKD) is a major cause of death and morbidity in Australia and worldwide. Current strategies that delay progression from CKD to end-stage kidney disease are limited. New treatment strategies are needed. Renal mononuclear phagocytes (rMP), conventionally comprising macrophages and dendritic cells (DCs), are known to play a central role in promoting progression of CKD. Definition of the role of individual subsets of rMP during the course of CKD is essential to understand the pathogenesis of CKD and define novel specific therapeutic strategies that target pathogenic subsets of rMP or use protective subsets to delay progression of CKD. The findings in the thesis demonstrate the phenotype and functions of rMP subsets in experimental CKD and their role in the pathogenesis of CKD, especially re-defining F4/80+CD11c+ cells as a macrophage subset in kidney, and highlighting the importance of interaction between CD103+ DCs and CD8 T cells in progression of kidney disease. These studies also provide evidence for the therapeutic potential of regulatory macrophages from different sources to delay progression of CKD. Novel and specific therapeutic strategies that target pathogenic subsets of rMP or use protective macrophages could be developed to treat chronic inflammatory diseases, including CKD.|
|Access Level: ||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions: ||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
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|CAO Qi - Final Thesis.pdf||Thesis||7.02 MB||Adobe PDF|
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