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|Title: ||The role of androgens acting via androgen receptor in uterine development and PTEN deletion induced uterine cancer|
|Authors: ||Choi, Jaesung (Peter)|
|Issue Date: ||31-Jul-2015|
|Publisher: ||University of Sydney|
Sydney Medical School
|Abstract: ||The androgen receptor (AR) is widely expressed in human and rodent uterus indicating an important role. However, the specific role(s) and mechanisms remain controversial. Hence, the thesis aimed to investigate the role of androgen actions via AR in uterine development, function and pathology.
Firstly, the uterine development and fertility appeared normal in uterine gland specific AR inactivated uterus suggesting AR mediated endogenous androgen actions in uterine gland epithelium are not critical in normal uterus. However, in the absence of estrogens, androgens via uterine AR can promote full uterine regrowth.
Secondly, PTENKO-induced uterine cancer incidence was significantly reduced by simultaneous global AR inactivation, indicating androgen actions via AR either systemically or locally within uterus modifies PTENKO-induced uterine cancer incidence. This could be due to reduced estrogen receptor alpha expression in uterus.
Thirdly, glandular epithelial AR inactivation enhanced PTENKO-induced uterine pathology. This could be due to reduced progesterone receptor expression in uterus suggesting glandular epithelial AR could regulate PR expression.
In conclusion, the thesis suggests a significant role for androgens via AR inducing uterine growth and pathology that could be mediated locally via AR present in glandular epithelial cells.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
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|CHOI Jaesung (Peter) - Final Thesis.pdf||Thesis||6.71 MB||Adobe PDF|
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