Please use this identifier to cite or link to this item:
|Title: ||Role of the Proteins of the Nuclear Envelope in Mesenchymal Stem Cell Differentiation|
|Authors: ||Bermeo Serrato, Sandra Milena|
|Issue Date: ||21-Aug-2015|
|Publisher: ||University of Sydney|
Sydney Medical School
|Abstract: ||The nuclear envelope (NE) provides stiffness to the nucleus, protects the genome, and regulates the mechanotransduction process via its network of proteins. These roles govern gene transcription and cell survival and/or differentiation. Considering that these proteins transmit cytoplasmic signalling to the nucleus through interactions with transcription factors, the identification and control of these interactions could play an important role in the regulation of cell differentiation and survival.
In mesenchymal stem cells (MSCs), it has been demonstrated that NE proteins are crucial to the differentiation process. Mutations in some of them are linked to envelopathies, in which mesenchymal tissues are differentially affected. In addition, during the ageing process, their level is decreased, which would explain in part some of the age-related changes in bone and muscle.
Lamin A, emerin and MAN1 are the most studied NE proteins in terms of their involvement in the pathogenesis of envelopathies. In this thesis we hypothesized that these NE proteins are involved in the differentiation of MSCs into bone and fat, playing a role in the pathogenesis of age-related bone loss. Therefore, this research thesis reports new evidence on the role of these three proteins during osteoblastic and adipogenic differentiation of bone marrow-derived human MSCs.|
|Access Level: ||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions: ||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
This work is protected by Copyright. All rights reserved. Access to this work is provided for the purposes of personal research and study. Except where permitted under the Copyright Act 1968, this work must not be copied or communicated to others without the express permission of the copyright owner. Use the persistent URI in this record to enable others to access this work.
|BERMEO Sandra - Final Thesis.pdf||Thesis||8.87 MB||Adobe PDF|
Items in Sydney eScholarship Repository are protected by copyright, with all rights reserved, unless otherwise indicated.