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|Title: ||Breast tomosynthesis: Novel detection of breast cancer|
|Authors: ||Alakhras, Maram Mustafa|
|Issue Date: ||12-Jan-2016|
|Publisher: ||University of Sydney|
Faculty of Health Sciences
|Abstract: ||Purpose: To evaluate the impact of adding digital breast tomosynthesis (DBT) to digital mammography (DM) on radiologists’ performance, confidence and identification of lesions. Also, to evaluate the radiation dose from DBT and DM and to assess image quality at different dose levels. Methods: Twenty six radiologists examined 50 cases in two modes, DM and DM+DBT. The radiologists were classified into three groups as having no DBT experience, workshop DBT and clinical DBT. Radiologists were asked to localize breast lesions, report their type and give a score of 1-5. The first study examined radiologists’ performance by: sensitivity, location sensitivity, specificity, ROC AUC and JAFROC FOM. The second study, using the same case set, looked at the radiologists’ confidence and their ability to identify lesion type. The third study was a phantom-based experiment to evaluate the mean glandular dose using DBT and DM. Eleven readers reported the visibility of lesions for all phantom images on both modalities. Results: All performance measures were significantly higher for DM+DBT compared with DM AUCs (0.788 vs 0.681, p< 0.0001) and JAFROC (0.745 vs 0.621, p< 0.0001). Similar results were obtained for readers with no DBT and with clinical DBT experience. The confidence of radiologists using DM+DBT was significantly higher than DM in scoring cancer (p<0.0001) and normal cases (p= 0.018). The number of stellate lesions correctly reported on DM+DBT was significantly higher than with DM (p< 0.0001). The radiation dose at a thickness of 50 mm was 13% higher for DBT than for DM. The visibility of lesions was acceptable at 50% mAs for DBT and for DM. Conclusions: Addition of DBT to DM significantly improved: radiologists’ performance whether or not they have DBT experience; radiologists’ confidence and the number of stellate lesions compared with DM. DBT radiation dose is slightly higher than DM dose. However, the exposure may be reduced by 50% mAs with no change in image quality.|
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|Rights and Permissions: ||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
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