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|dc.contributor.author||Liu, Paul Zhi Yuan||-|
|dc.description.abstract||Contemporary radiotherapy focuses on achieving the best patient outcomes by delivering highly targeted treatments that often include small fields and high dose gradients. Plastic scintillators outperform traditional dosimeters in these fields as they are close to water-equivalent. However, the translation of scintillation dosimeters into the clinic has been limited by three roadblocks.
The generation of Cerenkov radiation in an optic fibre irradiated by megavoltage radiation contaminates the scintillation signal. Two Cerenkov removal methods (spectral discrimination and air core) were found to be accurate in accounting for Cerenkov radiation and their clinical robustness was improved.
The light readout system is often the limiting factor for the accuracy of scintillators. PMTs outperform camera-based systems, though their implementation for array dosimetry is complex. A novel system with a multianode PMT was constructed and enabled multiple light signals from an array to be simultaneously measured.
Arrays of scintillation dosimeters are difficult to create due to the complex arrangement of detectors and their optical pathways. Two innovative approaches (square waveguides and 3D printing) were used to build prototype scintillation dosimeter arrays. These arrays showed that scintillation dosimeters can measure dose distributions with high spatial and temporal resolution.
Addressing these roadblocks has enabled the clinical translation of scintillation dosimeters. In small field dosimetry, an air core dosimeter was used as a reference to calculate and predict correction factors for existing dosimeters. For brachytherapy, an array of scintillators provided real-time dose measurements that improved the safety of the treatment. For rotational treatments, a cylindrical array was used to verify the dose delivered during simulated stereotactic treatments. Traditional dosimeters cannot be used in these applications and this demonstrates the potential of scintillation dosimetry.||en_AU|
|dc.publisher||University of Sydney||en_AU|
|dc.publisher||Faculty of Science||en_AU|
|dc.title||The clinical translation of plastic scintillation dosimetry||en_AU|
|dc.type.pubtype||Doctor of Philosophy Ph.D.||en_AU|
|Appears in Collections:||Sydney Digital Theses (Open Access)|
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|2015_Paul_Liu_Thesis.pdf||Thesis||53.01 MB||Adobe PDF|
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