Please use this identifier to cite or link to this item:
|Title: ||Effects of Dietary Sphingomyelin on Non‐alcoholic Fatty Liver Disease and Atherosclerosis|
|Authors: ||Chung, Wing Shan Rosanna|
|Issue Date: ||28-Nov-2014|
|Publisher: ||University of Sydney|
Heart Research Institute
|Abstract: ||Sphingomyelin (SM) is ubiquitous in human diets. The studies in this thesis investigated the effects of pure egg SM supplementation on the risks of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis development in various mouse models. High fat-fed C57BL/6 mice, a model for NAFLD, was supplemented with different doses of dietary SM for various duration. The results showed that SM supplementation significantly reduced hepatomegaly, total hepatic lipids, particularly hepatic cholesterol and triglyceride, in a dose-dependent manner after 4 weeks. All of these parameters are risk factors of hepatic steatosis, the first stage of NAFLD.
Dietary SM was also supplemented to either high fat-fed or chow-fed apoE knockout mice, a model for atherosclerosis. Results indicated that dietary SM did not increase circulating SM, a risk factor of atherosclerosis, nor atherosclerosis development after 16 weeks. At week 19, dietary SM was shown to significantly reduced atherosclerosis development in chow-fed apoE knockout mice. Collectively, studies in this thesis provided evidence that dietary SM can be used to prevent NAFLD in mice. This work lays the groundwork for future investigations into the potential therapeutic benefit of dietary SM on NAFLD and atherosclerotic lesion development in humans.|
|Access Level: ||Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library.|
|Rights and Permissions: ||The author retains copyright of this thesis. It may only be used for the purposes of research and study. It must not be used for any other purposes and may not be transmitted or shared with others without prior permission.|
|Type of Work: ||PhD Doctorate|
|Type of Publication: ||Doctor of Philosophy Ph.D.|
|Appears in Collections:||Sydney Digital Theses (University of Sydney Access only)|
This work is protected by Copyright. All rights reserved. Access to this work is provided for the purposes of personal research and study. Except where permitted under the Copyright Act 1968, this work must not be copied or communicated to others without the express permission of the copyright owner. Use the persistent URI in this record to enable others to access this work.
|CHUNG Rosanna - Final Thesis.pdf||Thesis||4.11 MB||Adobe PDF|
Items in Sydney eScholarship Repository are protected by copyright, with all rights reserved, unless otherwise indicated.